Frank is put on the spot when a supporter for the mayor is found dead and the mayor wants Frank to position it as a random act of violence to the public. Meanwhile, Jamie goes on his first undercover assignment at a bar where meets and bonds with a suspicious patron.

Frank deals with a political crisis after Jamie and Renzulli are injured by a church security team that refuses to let them enter a religious center in response to a 911 call.

Henry's heart attack on Thanksgiving eve leaves the family contemplating a future without him. While Danny and Jackie look into a suicide that may not be what it seems, Frank and the mayor disagree about a threat to the city.

When a man’s family is robbed and beaten in front of him, and the assailant is shot and killed, the Reagan’s debate about how far they would go to protect their family. Meanwhile, when a college student is arrested at a rally, Frank wrestles with her sentence due to her identity.

Danny is put in a difficult position when a gun linked to a robbery is brought in to the NYPD’s gun buyback program. He must decide to either arrest the suspect or follow the no questions asked rule.

Danny and Jackie are assigned to protect a key witness in a Russian mob trial, but when an attempt is made on her life, they realize there is a leak on the task force. Meanwhile, Erin is offered a job as deputy mayor, which would have her working directly with her father.

Frank must race to stop a biological weapon attack on New York City, while keeping it a secret from his family during their most sentimental holiday, Mother’s Day. Meanwhile, a long-standing conflict between Danny and Jamie comes to a head.

When two motorists driving gas-guzzling cars die at the hands of a sniper, Danny and Kate are put on the case of what the city believes is the work of a radical environmental serial killer. Meanwhile, a bicycle accident sends Danny’s son Sean to the hospital with a life-threatening injury.

Jamie must deal with the emotional consequences of his actions on the job. Meanwhile, Erin questions Mayor Poole on the witness stand.

When a man with multiple rat bites is thrown from a moving car, Danny works the case to find out why and who was trying to send a message. Meanwhile, Frank must be diplomatic when dealing with a bigoted radio host who will be broadcasting from New York City.

Danny blames himself when a young woman commits suicide because he had made a promise to her in the wake of her parents' deaths. Meanwhile, violence involving a gang at a housing project erupts and affects the Reagans.

As the Reagans rally together to take down the leader of the gang responsible for the murder of someone close to them, Danny looks to the gang leader’s girlfriend to lead them to him. Meanwhile, Frank is left reeling from a second loss.

When an officer is accused of using excessive force on a suspect, Frank finds his department under scrutiny from the community and the mayor. Meanwhile, Danny and Baez investigate the murder of a Wall Street securities trader who was deep in debt due to a gambling addition.

Danny’s loyalty is tested when he is assigned to the case of a childhood friend, Mickey, who is under investigation for having ties to an infamous mob family. Meanwhile, Frank gets word that crime is on the rise due to a recent judicial ruling about the legality of the “stop and frisk” policy.

Danny tries tracking down the drug cartel who's attacked a convoy of drugs been transported to be incinerated. Baez is left injured. Frank treads carefully.