Danny and Jackie set out to investigate the murder of a bride on her wedding day in a drive-by gang shooting. However, they are pulled off the case and assigned to the protection detail of a Central American president, who they believe is a target for assassination. Meanwhile, Jamie questions his partner Vinny’s methods when he performs an unjustified stop.

As the Reagans rally together to take down the leader of the gang responsible for the murder of someone close to them, Danny looks to the gang leader’s girlfriend to lead them to him. Meanwhile, Frank is left reeling from a second loss.

Danny becomes the lead hostage negotiator when a prime informant in a large drug case holds Erin at gunpoint inside the courtroom.

Erin and Anthony try to prevent the deportation of a prominent community activist who isn't a citizen. Frank must decide if the NYPD will participate in the U.S. Marshals' high-profile raid of a local gang.