When a rich woman dies of a heart attack, her eccentric daughter claims that she received a message from God, who told her that her stepfather actually murdered her. Meanwhile, the archbishop wants Frank's support for the canonization of a local priest, but a reluctant Frank takes it upon himself to investigate a rumor that the priest went too far when protesting the Vietnam War.

When Danny and Kate come up empty-handed with leads for a shooting, Linda helps make a break in the case when she overhears the victim telling his priest who is responsible. Meanwhile, Henry is mugged at an ATM, which sends Jamie into a rage as he tries to track down the assailant.

Danny’s car matches an NYPD description of a car involved in a drug deal and taken into custody when a bag of cocaine is found in his trunk.

When the same tragedy occurs to people who don’t appear connected, Danny must find what they have in common and who is responsible. Meanwhile, Frank helps an old friend come to terms with his alcoholism.

When an armed robbery ends with the death of a police officer, Frank makes it a mission for the NYPD to bring the suspect to justice. However, tensions run high in the Reagan household when Erin drops the charges and releases the suspect due to lack of evidence.

Frank is put in danger when his dinner companion, mob lawyer Angelo Gallo, is shot; Danny is a juror in a murder trial.

Danny is after the distributor of a deadly new street drug.

When Danny takes a call from a woman who is threatening to kill herself along with the man who killed her parents in a drunk driving accident, he rushes to find her. Meanwhile, Frank accompanies his grandson, Sean, on a class field trip and struggles to get the lead chaperone to loosen the reigns so the kids can have fun.

Danny uncovers shocking information while investigating a case against orders.

Danny tries tracking down the drug cartel who's attacked a convoy of drugs been transported to be incinerated. Baez is left injured. Frank treads carefully.

An interview goes badly for Frank after he ends up being blindsided by the interim district attorney. Danny and his new boss deal with a drive-by shooting.

Evidence against Danny surfaces when the attorney general's office reviews his shooting of a serial killer. Jamie and Eddie deal with a high-profile drunken driver. A slain cop's widow asks Frank for a favor.

After Emily Harrison tells Danny and Baez she's concerned her abusive ex-boyfriend will repeat his behavior with his new girlfriend, Emily becomes the prime suspect when he's murdered. Also, Eddie gets jealous when Jamie lets a young woman crash at his apartment, and Frank must decide how to discipline a sergeant after he fails to intercede during an armed robbery while off duty.

When the son of Frank's most outspoken critic in the African-American community, Reverend Darnell Potter (Ato Essandoh), is killed, Potter must put aside his contentious relationship with the Reagan family in order to get justice for his.

When Linda's brother, Jimmy, gets into trouble with the mob, he begs Danny to help him stay safe until it blows over. Also, Frank faces a public relations nightmare when the lawyer of a wrongfully arrested man demands that NYPD records be made public.

An ex-NYPD officer goes missing the day after she reveals to Danny her plans to make amends to the woman she and her partner wrongfully convicted years ago. Frank faces a dilemma when one of his peers refuses to retire.

In the season finale, when Danny intercepts a shipment of several million dollars that was heading to a drug cartel in Mexico, he becomes a target when they come back for revenge. Also, Jamie works independently to track down a serial killer who preys on the elderly.

Danny considers retiring until Erin asks for his help with a case involving her ex-husband; Jamie and Eddie pose as a couple; Frank clashes with the new mayor.

Danny and Baez work the case of a detective who was gunned down prior to testifying against a career criminal. Meanwhile, Frank personally investigates when Garrett is attacked by a S.W.A.T. team outside his home; and Erin brings in a confidential informant against Anthony’s wishes.

A case turns personal for Danny when he works to protect a nurse, Faith Madson, from her violent ex-boyfriend. Also, Shelly Wayne, an acquaintance of Frank's, comes to him with a theory regarding the death of an inmate, and Jamie and Eddie help deliver a baby.

Jamie and Eddie ask Erin to drop old charges against a man who bravely rescued a woman from a local hostage situation; Danny and Baez work a case involving car thieves and discover the leader is a mobster they've dealt with before.

Danny considers taking a new job that would ease his financial struggles after investigating the death of a wealthy man. Also, Nicky tries to avoid involving her family when she is sexually harassed by her boss at her new internship, and Garrett advises Frank to regain the public's trust after a rookie cop is caught on video questioning a pedestrian's immigration status.

Danny and Baez race to find a missing girl who will die within 72 hours without her heart medication. Also, Jamie and Eddie are on the wrong side of an investigation after engaging in a car chase, Frank, Garrett and Gormley investigate the rise in the settlement of lawsuits against cops, and Sean wins an essay contest and receives a medal from former New York City Mayor David Dinkins.

When a series of drive-by murders occur after six wrongly convicted men are released from prison, Danny and Baez wonder if they were orchestrated by the men as an act of revenge. Also, Frank combats the guilt he feels about these innocent men unfairly serving nine years in prison, and Jamie and Eddie find themselves in a life-threatening situation.

Things get personal for Danny when the drug cartel hit man responsible for torching his house resurfaces. An attack on an officer in the line of duty directly impacts a member of Frank's team. Eddie reluctantly introduces Jamie to her mother.

Frank questions whether a run-in with community activists was an accident or a setup. Also, Jamie strives to rely less on Frank’s input to makes decisions, Erin helps Anthony protect his daughter and ex-wife from a dangerous psychiatric patient, and Danny and his neighbor size each other up when they learn their kids are dating.

While off duty, Danny encounters a gas station robbery in progress and is forced to use his weapon, leaving him shaken and his family and co-workers concerned. Also, Eddie apprehends a turnstile jumper who pleads for leniency by offering information on a missing weapon that's vital to one of Erin's cases, and Frank learns that a top officer in his department has a dark past.

After someone breaks into Luis Delgado’s home and kills his wife, Luis and Danny team up to take down the vicious murderer who may also be responsible for Linda’s death. Also, Frank finally meets Eddie’s mother, Lena, and Jamie and Erin are at odds after Jamie seeks her help charging a man who confessed to him while under the influence.

As Jamie and Eddie's wedding day approaches, Frank worries about the toast he'll deliver at their rehearsal dinner. Also, Erin interviews a witness whose story leads her to doubt Eddie's honesty, since she took his initial statement, and Danny and Baez unravel the complicated love life of a young homicide victim.

Danny and Baez grapple with a homicide investigation brought to their attention by Maggie, the medium who previously helped them solve a case; Frank looks for a way to help his ex-partner Lenny Ross when Lenny's daughter gets arrested.

After a woman is found dead at a men's-only club, Danny and Baez investigate if her death was an accident; Frank hears about an alleged affair between the chief of Internal Affairs and the spouse of another member of law enforcement.

A widow blames Frank for her husband's recent suicide; Eddie has a gut feeling about a murder; a desperate Luis Delgado wants protection for his sons.

After getting a match from an unknown relative from a DNA network, Sean Reagan does some detective work to figure out who this mystery person might be. Frank gets a personal request from a woman to transfer her son to a safer assignment. Also, Danny seeks to uncover the truth behind the murder of a key witness in one of Erin's cases, and Eddie begins to think about having a child after she and Jamie discover a newborn left outside their precinct.

Amidst a shifting political climate, Frank goes head to head with City Council Speaker Regina over protests against police brutality. Also, Jamie and his nephew Joe Hill work together to locate Danny and Baez when they go missing while searching for a killer, and Eddie steps up to help an abrasive woman find her father's body after it was misplaced during the outset of the pandemic.

Frank struggles after Joe Hill's lineage as a Reagan is revealed; Erin and Anthony receive gift-wrapped evidence; Danny's opposition to authority clashes with Jamie's adherence to the rules, as both brothers work to solve a murder.

The Reagans confront hard choices on the job when Frank deals with a police captain who's losing his grip over his precinct, and Danny faces backlash from the Baez and Internal Affairs over a tough call he made in the field.

Erin tries not to feel overpowered as her new boss shadows her at work just as she's trying to get a nervous eye-witness to reveal the identity of who shot her boyfriend. Also, the serial killer who previously held Danny and Baez hostage resurfaces, and when Jaime arrests an intrusive reporter who appears at a series of store lootings, it leads to a standoff between Frank and the Attorney General over the press' First Amendment rights.

Frank asks Erin to liaise between him and NY Governor Mendez regarding policy reform he privately backs, but can’t publicly support, because it goes against police rank and file. Danny and Baez become enmeshed in the world of competitive gaming when a high-profile video game streamer is murdered, and Eddie and Witten suspect a live-in nanny is being abused after she approaches them on the street for help.

Jamie refuses to explain why he contests the arrest report of a fellow officer who was assaulted in the field; Danny and Baez clash when their lead suspect for a murder of one of Danny's favorite comics.

The Reagans band together to prevent Joe Hill from being killed in the line of duty like his father when they fear Joe’s cover has been blown within the gunrunning outfit he’s helping the ATF bring down.

Jamie and Eddie experience marital tension when Eddie allows her newly released ex-convict father to live with them; Danny and Baez go out of their way to help a desperate man find his missing sister.