In front of a live audience of 14,000 at London's O2 arena Alan Carr, Andy Parsons, Bill Bailey, Catherine Tate, Christine Bleakley, David Mitchell, The Fonejacker, Jack Whitehall, Jack Dee, James Corden, Jason Manford, Jo Brand, John Bishop, Jonathan Ross, Kevin Bridges, Kevin Eldon, Lee Evans, Mark Watson, Michael McIntyre, Noel Fielding, Patrick Kielty, Rich Hall, Rob Brydon, Ruth Jones, Sean Lock, and Shappi Khorsandi take turns on stage to make it the biggest live stand up show in UK history. Added to this, Stomp perform two major routines with Alan Carr and Bill Bailey. Plus, Robert Webb, Ricky Gervais, Derren Brown, Kevin Bishop, Jimmy Carr, Gok Wan, Stephen Merchant and Johnny Depp provide additional sketches.

For one night only, the O2 Arena played host to Channel 4's Comedy Gala 2010, the UK's biggest stand-up show featuring 35 of the biggest and best comedians our homeland has to offer. They all performed in aid of Great Ormond Street Hospital. These are the Best Bits from the performance.

The UK's biggest stand-up show is back for a second year. Channel 4's Comedy Gala, in aid of Great Ormond Street Hospital, returns with a two and a half hour special. Dermot O'Leary opens and closes the show with an all-star line-up including: Alan Carr, Andi Osho, Chris Moyles, Dara O Briain, Jack Dee, Jack Whitehall, Jason Byrne, Jo Brand, John Bishop, Jon Richardson, Jonathan Ross, Kevin Bridges, Lee Evans, Mark Watson, Michael McIntyre, Micky Flanagan, Rhod Gilbert, Rich Hall, Sarah Millican, Sean Lock and Shappi Khorsandi. The show features music from N-Dubz and Irish band Dead Cat Bounce, who perform a special tribute to all those taking part. There are exclusive video inserts from Lady Gaga, Russell Brand, Miranda, Whoopi Goldberg, Glee actors Jane Lynch and Matthew Morrison, along with James Corden and Sir Patrick Stewart. Plus, Rob Brydon's own unique film of his journey to The Gala - with a helping hand from a few of his chums.

Channel 4's Comedy Gala returns for a third year as some of the nation's best-known and most-loved comedy and music stars share the stage for this iconic charity event. Headlining this year's extravaganza - filmed at London's 02 Arena in aid of Great Ormond Street Hospital - is Jessie J, who opens the show with an exclusive live performance. The all-star line-up also includes Lee Evans, Michael McIntyre, Jonathan Ross, Micky Flanagan, Sean Lock, Kevin Bridges, Jo Brand, Jack Whitehall, Jack Dee, Jon Richardson, Seann Walsh, Lee Nelson, Josh Widdicombe, Paul Chowdhry, Andi Osho, Keith Lemon, Reginald D Hunter and Alan Carr.