Miller's overbearing mother is going to write him off as her son since he is an idiot and not married yet. To impress her, Miller claims that he and Murphy are friends. Because Murphy is uncomfortable around Miller, his mother suspects they might be more than friends. Something he doesn't readily deny.

Murphy begins her chemotherapy treatments. The treatments make her uncomfortable and take a lot out of her. She confronts Jim about his avoidance of her and her condition. In an effort to help her out, Jim purchases some marijuana to help ease her pain. They light up and deal with their issues.

Frank signs his new contract; Murphy is in the midst of negotiating her new deal. After Murphy can't make her appearance on the show, Corky fills in and does a great job conducting the scheduled interview. The network brass wants to give Corky the chance to report from the Middle East. The network only offers Murphy a one year deal instead of the usual three year deal and Murphy won't back down until the network meets her on her terms.

Corky is working to help the zoo with their charity auction. Murphy's bout with cancer has made her realize there may not another chance to do some of the things she'd like to do. When the one item goes up for bid that she is interested in, it's Murphy Brown vs. Olivia Newton-John for the right to conduct a symphony orchestra. Meanwhile, Doris tells Jim that it is time to file the divorce papers; Murphy encourages him to fight for her.

Murphy's new secretary makes a great cup of coffee, but doesn't have time for much else. Murphy receives a call from a former Wall Street trader who has just been released from his prison sentence for insider trading and he wants to be interviewed on the show. During the on camera interview, he proposes to use some of his money to hold a benefit run for breast cancer research, which he would like Murphy endorse. Later, off camera, she does and really thinks that he might have changed when everything seems to go right with the event. Until he tells her that he doubled the million dollars they rose. She also discovers that public opinion is split, not on what she did, but who she did it with.

The chemotherapy begins to take its toll on Murphy's hair. She begins to wear a wig and attend support group meetings.

Murphy battles insomnia and the gang helps her to get through the night. Frank, while he is on a stakeout with a SWAT team. Jim, while he is working on getting back together with Doris. Corky, while she is going through her storage locker of memories. Kay, who was up anyway, helps Murphy make and bake cookies from scratch, over the phone.

Murphy is done with her chemotherapy and she thinks that is the best birthday she could get for her upcoming 50th birthday. Frank and Murphy decide that it might be interesting to try going out on a date together. Frank has to cut the date short, because has a big surprise planned for Murphy's to go out on a date that Frank has to cut short so that he can get Franks plans a big surprise for Murphy's birthday. He has American Bandstand recreated in the FYI studio, complete with Dick Clark and variety of featured artists.

To prove her point about gender identification, Kay shows up at Phil's dressed as a man. The disguise fools the staff and Murphy uses Kay in her disguise to stop the advances of an IRS tax accountant that has information Muprhy needs for a big story. Unfortunately, the poly jeopardizes Murphy's chances at the story. The staff tries to help Murphy rescue her story.

Murphy finds a secretary that she likes; only nobody else likes his abrasive approach. Jim is planning a rendezvous with Doris in Maine. When he tries to go through the metal detector at the airport he is found to be in possession of a small quantity of marijuana, the marijuana that he purchased to help Murphy get through her chemotherapy. He dismisses it all as a minor inconvenience until the press gets hold of the story. In the ensuing media frenzy, Jim prefers to remain silent, Murphy thinks it would be better to tell the truth and when she does, Jim stops talking to her.

Murphy fires her last secretary, she plans on leaving FYI, it has been six months since her last chemotherapy treatment. She wants to live the rest of her life. Jim mentions it might be time for him to go as well. The rest of the staff tries to come to grips with the situation. Meanwhile, shooting on location down the street, Julia Roberts stops by the offices of FYI hoping to meet Frank Fontana. To be free and clear of cancer, Murphy needs to get another mammogram. Unfortunately, the mammogram shows something that will require exploratory surgery to uncover its nature. Seeking comfort, Murphy reflects on the need to talk with Phil and no one is more surprised than she is when he returns from the dead. Seems he knew too much about Whitewater. Murphy goes under the knife as the gang waits outside. Murphy has an out of body experience that brings up to heaven to conduct the only person she hasn't interviewed, God.