Baretta has to go on the run to clear his name after he is framed for the murder of a gun dealer he was investigating, who was selling weapons to teenagers.

Baretta must use his wits to survive after he and a runaway girl he apprehended unwittingly get into a police car being driven by a couple of holdup men disguised as cops.

While Baretta is investigating a series of waterfront killings, his cover becomes in danger of being blown by a waitress who knows him and thinks he is responsible for the death of her boyfriend.

Baretta poses as the trainer of a former champion boxer to trap a drug-smuggling murderer.