Three incoming freshman attending college football powerhouse Blue Mountain State University must quickly adapt to college life while juggling football, girls and nonstop hazing.

After a streak of bad luck, the team holds a "Lock-In Party" at the Goat House to build team camaraderie at which Alex and Thad divide the rest of the players into two groups and compete in a drug-fueled Team Building Olympics.

When Alex has sex with a lacrosse player's girlfriend, he unwittingly breaks a 23-year football/lacrosse team truce, causing a take-no-prisoners war which he must figure out how to end.

The team becomes celibate in order to boost their performance on the field, but it backfires when Mary Jo, out of frustration, stirs them into a frenzy. Plus, Coach Daniel's ex-wife Debra shows up to collect unpaid debts.

Alex, Thad, and Radon receive a message from an unknown woman saying she is pregnant and each respond very differently. Meanwhile, Sammy must decide between staying with a girl out of his league at a price or to go back to being single while Coach Daniels attempts to rekindle his relationship with his son.