After escaping from Central Prison, the Freezing Alchemist, Isaac McDougal, sets his plan in motion to kill Führer King Bradley. However, under the command of Lt. Col. Roy Mustang, the military and State Alchemists attempt to stop him.

Hohenheim's visit ends with a grave warning to Pinako, but Ed finds hope among the charred ruins of his childhood. Now more than ever, he has confidence that Al can be returned to his body.