Addison and Pete treat a recently married couple who are having sexual problems. Cooper is trying to figure out why four siblings are all suffering from the same mysterious illness. Maya tells Naomi she's been hoping her and Sam would divorce since she was in the third grade. Meanwhile, Violet is trying to convince a patient to leave her husband, even though, she is having trouble letting go of her ex-boyfriend who is now married.

Addison and Charlotte fight to save the lives of a woman in a coma and her unborn child; members of the Oceanside staff clash with Meg; when a patient is suspected of murdering his wife, Violet seeks Kevin's advice.