Addison butts heads with a new oncologist (Cristian de la Fuente) while treating a newborn with a malignant tumor; Pete is uncomfortable when Violet tries to help a parolee.

Addison's mother, Bizzy, aggressively demands her daughter do whatever it takes to save her partner from dying - including working with Dr. Rodriguez once again. Meanwhile Amelia and Pete's medical consultation is complicated when a patient's wife and his mistress disagree on the course of treatment, Charlotte and Cooper try to be intimate with each other again, and Violet considers publishing a personally-revealing book she's written.

Addison plans Bizzy and Susan's wedding while trying to keep her distance from the overly flirtatious Dr. Rodriquez. Sam is concerned about the care his longtime patient is receiving, and Sheldon refers Charlotte to his mentor and friend for psychiatric help.

Charlotte's attacker, Lee Henry, arrives at St. Ambrose Hospital, injured by his girlfriend and in need of urgent care, and Sam and Charlotte must decide whether or not to save his life. Meanwhile, Susan's health takes a turn for the worse, and Addison's mother, Bizzy, begs her daughter to do everything in her power to help.