Brooke and Sam try to derail their parents' wedding plans by planting false evidence of Mike's infidelity, which leads to a startling announcement from Mike and Jane. Meanwhile, Mary Cherry discovers that her mother is engaged to actor Erik Estrada.

Harrison is checked in a hospital for treatment for his leukemia. His roommate is a religious fanatic, which makes him quite uncomfortable. Harrison doesn't want anybody's help and yells at Brooke. Brooke is faced with the ghost of her anorexia and fears coming back to the clinic she once was. Sugar Daddy feels miserable for his looks and checks into a clinic for food disorders (which happens to be the same hospital where Harrison is.). Mike hears somebody throwing up in the bathroom. First he thinks it might be Jane, but he realizes it's Brooke and puts her in the clinic. Sugar feels very depressed and has a fight with Brooke. Later she advises him to talk to one of the girls at the clinic, and she plays cupid slipping a love letter under her door. But the clinician gets the letter instead. Sugar feels guilty and tells Ashley that he didn't write the letter, without knowing that she never got the letter in the first place. Harrison's roommate has a seizure, just as he was starting to

Lily, in an effort to defend a fellow student who has been suffering jokes about his lifestyle, starts the G.L.A.S.S. (Gay and Lesbian Alliance of Supportive Students), which causes a lot of repercussion around the school, and not such great support from people as she expected. But prejudice is not only about sexual choices, as Sam and George have to deal with the comments on their interracial relationship; Sugar D. doesn't get a job for being fat and Jamie (Brooke's date) reveals that he has suffered prejudice because of his religion. Things get hot when Lily is hospitalized after being attacked when she was leaving a g/l community center (which she took Miss Glass to get information about her sexuality). The gang realizes that hate will never lead to anything, and join the group one by one. Bryan comes out of the closet in a gesture of support after the group is cancelled.