The fate of Enterprise is in Dr. Phlox's hands as the rest of the crew must be induced into a coma in order to survive a trans-dimensional disturbance.

While dissension among Xindi ranks festers, Enterprise tries to recover from a devastating attack.

With help from Xindi allies, the Enterprise crew attempts to stop the arming of the Weapon aimed toward Earth.

With Silik's help, Archer hones in on the temporal operative who altered Earth's past and threatens to destroy all of time.

When genetic supermen left over from the Eugenics Wars hijack a Klingon ship, Archer must rely on their creator, the criminal Dr. Arik Soong, to help hunt them down.

Archer, T'Pol and T'Pau attempt to bring the Kir'Shara — an artifact believed to contain Surak's original writings — to the Vulcan capital, as the NX-01 gets involved in a Vulcan-Andorian military clash.

Non corporeal aliens study the Enterprise crew as they respond to a fatal viral infection brought on board from an away mission.

Archer visits Shran's icy homeworld to find an Andorian subspecies called the Aenar, to determine their connection to the marauder destroying ships in the region.

In the mirror universe, Commander Archer mutinies against Captain Forrest in order to capture a future Earth ship found in Tholian space.

In the mirror universe, Archer commandeers the 23rd-century Defiant from the Tholians and uses it in a nefarious power grab.

Six years in the future, an emotional Captain Archer and the crew return to Earth to face the decommission of Enterprise and signing of the Federation charter.