When Archer and Trip are invited to a desert-like planet by an alien leader, they discover he is a terrorist who has lured them there under false pretences. Meanwhile, T'Pol, while in command, faces a tough decision when she cannot locate Archer and Trip in the desert.

Archer spends a night in sickbay with Dr. Phlox after Porthos contracts a deadly virus on the Kreetassan homeworld. Crew members suspect Archer's increased stress level is due to Porthos' illness, but Dr. Phlox suspects it has to do with Archer's repressed sexual tension.

Hoshi experiences her first transporter experience and strange aftereffects lead her to believe she wasn't reassembled correctly.

Both the Vulcans and the Andorians make a claim to a small planet and military conflict soon erupts. As the fighting goes on, the Vulcans announce they are willing to discuss cease fire terms. However, Imperial Guard officer Shran believes only Captain Archer can be trusted to mediate the situation, which drags the Enterprise crew into the tense situation.

Enterprise starts experiencing effects of the spatial distortions pervading the Delphic Expanse, and falls victim to predatory aliens.

Archer, Reed and Major Hayes infiltrate a Xindi-Sloth industrial colony to learn more about the weapon of mass destruction that will be used against Earth.

When a settlement of humans living a 19th-century Western lifestyle is discovered on a Delphic Expanse planet, Archer and crew set out to learn how they got there.

With Silik's help, Archer hones in on the temporal operative who altered Earth's past and threatens to destroy all of time.

The inventor of the transporter, Emory Erickson, comes aboard Enterprise for a risky experiment.

Enterprise journeys to Babel with a Tellarite ambassador on board for peace talks with the Andorians, when a distress call from Shran is received.