当Narn攻击Centauri的殖民地时，Londo和G'Kar差点发生冲突；与此同时，袭击者正在袭击空间站附近的运输船。

一艘严重受损的飞船被带进空间站，里面的奇怪外星人为灵魂猎人：一个可以感知死亡并偷走它人灵魂的不朽种族。

Londo不知不觉地爱上了一个美丽的奴隶，奴隶主想让她窃取敏感信息。Garibaldi发现有人正在使用一个受限的通信通道。

医生的一位老朋友兼前导师、异种考古学家Vance Hendricks 拜访了他，希望医生能帮助、分析他在一个异世界上发现的有机文物；但这文物似乎有自己的意愿，并开始操纵Hendricks的助手。

指挥官Sinclair的旧情人Catherine在为期一周的节日期间到来，届时人类和外星人将展示他们各自的宗教信仰；一个宿敌派了一名刺客去杀G'Kar。

心感警察到达空间站，捕捉一个变节心感成员-Ironheart心感军团教官；Catherine被G'Kar警告不要调查Sigma 957星。

一个种族主义团体在巴比伦5号上恐吓非人类。与此同时，Londo遇到Centauri星两个年轻人，他们打破传统，无视包办婚姻，为爱结婚。

Sinclair指挥官被两名男子绑架并审问，他们决心证明他在前线战役中与外星人勾结背叛了地球，但却使指挥官恢复了脑中缺失的记忆。

Na'Toth攻击了一名刚到空间站的外星女子，声称她就是Dilgar战犯Jha’dur，也称夺命者。与此同时，心灵感应师Talia被Kosh雇佣来监督一个相当奇怪的谈判。

一对外星夫妇带着病入膏肓的儿子来找医生治疗，这个孩子可以通过简单的手术治愈，但父母的宗教信仰不允许手术。与此同时，Ivanova护送一艘受损的星际船穿过突袭者的领地。

就在总统访问巴比伦5号的前几天，空间站一码头发生了爆炸。一个受伤垂死的男人牵连到Garibaldi，这正是总统安全负责人想要听到的，因为她把父亲的死归咎于Garibaldi。

在停靠舱发生事故后，空间站的码头工人举行了游行罢工。G'Kar试图参加Narn的宗教仪式，但必须找到在事故中被毁的G'Quan-Eth花的替代品。

一位Centauri贵族来到巴比伦5号，欲将Londo购买的一件重要遗迹运回国内。一神秘男子Morden拜访了所有的外星大使，向他们提出了一个不同寻常的问题。

Garibaldi一位老朋友来到巴比伦5号，参加在“Mutai”一个野蛮的外星战斗竞技场中竞技。与此同时，Ivanova在处理父亲的死亡时遇到了麻烦。

一名男子来到巴比伦5号，向外星大使询问可以帮助他寻找圣杯的信息，而一名地下黑帮则通过杀掉所有反对他的人来解决走私问题。

地球督查组和心感团军事专家抵达巴比伦5号，检测空间站指挥阶层对地球的忠诚度。Lennier对Garibaldi组装1990年代摩托车表现出极大的兴趣。

一艘Minbari巡戈战舰来到巴比伦5号，展示一位最近去世的Minbari战将的遗体，而 Ivanova和Talia则为一位拥有心灵感应能力的年轻女孩的命运而战。

奇怪的信号来自巴比伦5号下方的行星Epsilon 3。一艘科学船被派去调查，但遭到了星球上防御系统的还击。与此同时，Garibaldi 担心他在发生内战中火星上的情人。

当地球联盟的一艘重型巡戈舰抵达空间站，以“保护地球利益”，局势加剧，Epsilon 3号上的聚变反应堆开始失控，并可能炸毁星球和空间站。

巴比伦4号在四年前消失的地方再次出现，Sinclair和Garibaldi率领探险队疏散船员。与此同时，Delenn被灰色委员会任命为新的领袖。

医生在空间站穷人区调查一名未经许可的行医者，而Londo则带着Lennier参观了巴比伦5号的地下红灯区。在禁闭室里，一名被定罪的杀人犯等待着他的判决——人格死刑。

Quadrant 37星前哨战遭突袭，Narn损失惨重，G'Kar离开空间站前去调查。与此同时，Garibaldi试图找出他线人死亡原因时遭到暗算；地球联邦总统Luis Santiago遇袭身亡；Delenn化蛹进行转变；巴比伦5号在十字路口...

谢里登来到巴比伦5号，取代辛克莱，并处理一艘叛变的米巴里巡洋舰。

谢里登的妹妹来拜访他在新指挥部的他，G'Kar带着来自已知空间边缘的严重消息返回，弗兰克林博士试图用从罗森博士那里获得的外星治疗设备唤醒格里巴尔迪，而且德琳的房间里正在发生一些事情。

一个被称为“技术法师”的神秘团体在巴比伦5号暂时居住，隆多非常渴望与他们见面。与此同时，德拉齐人用他们相当不寻常的选举过程给新晋升的指挥官伊凡诺娃造成了问题。

一艘巨大的探险级船舶来到巴比伦5号补给——船长是谢里登的老朋友。当弗兰克林博士开始分发“食物计划”时，他激怒了指挥部的其他成员。

一艘有100年历史的太空探索船出现在巴比伦5号附近，上面有两名乘客：一个在低温睡眠中的女人，她丈夫的尸体，以及一个与半疯的潜伏者有未了的恶意事物。

塔莉娅的一个朋友来到巴比伦5号，谈判一项协议以帮助火星变得更加自给自足，当一个男人喊着“自由火星！”电死他时。

隆多召集他的三个妻子到巴比伦5号，这样他可以和其中两个离婚，塔莉娅接待了她讨厌的前夫——唯一一个离开PSI军团的男人，德琳经历了她的第一个糟糕的头发日。

贝斯特返回巴比伦5号，关闭一个地下组织，该组织将逃亡的心灵感应者偷运出PSI军团的触手。同时，谢里登与地球力量就他的住宿费用发生了一些分歧。

衰老的半人马座皇帝不顾健康状况恶化，仍前往巴比伦5号。雷法看到这是一个机会，让隆多公开羞辱皇帝，同时G'Kar准备刺杀他。

当25,000名地球力量士兵到达时，巴比伦5号出现了相当大的空间问题。他们由理查德·弗兰克林将军领导，斯蒂芬·弗兰克林的父亲，他们将使用巴比伦5号作为一个冒险军事行动的起点。

谢里登领导一支星怒战斗机中队调查几艘船只的失踪，他被一艘外星船只捕获。与此同时，德琳被召唤到灰色议会，讨论她最近外貌的变化。

G'Kar努力控制巴比伦5号上的纳恩人，他请求不同的大使帮助对抗半人马座的战争。伊凡诺娃向一个新物种的代表展示空间站，这样他可以决定人类是否值得他们存在。

总统的医生逃到巴比伦5号，躲避地球力量特工的追捕。他们说他有计划卖给外星政府的机密信息，但谢里登很快就了解到了其他情况。

谢里登被米巴里的洛维尔袭击，并被迫自卫杀死他。但是，一个目击了这一事件的米巴里声称谢里登先发制人，并且大家都知道米巴里不会撒谎。

我们通过ISN的眼着看巴比伦5号的生活，辅以采访、统计数据，甚至一些商业广告。

谢里登震惊地得知，伊卡洛斯号上的船员之一——即他妻子所在的科学船发生爆炸而死——居然还活着，那就是莫登先生。和平部的一名代表来到空间站，招募人员加入夜间警戒。

隆多接待了一个老朋友，他在被中央议会称为叛徒后寻求他的帮助。谢里登在被一个死去的外星人攻击后开始产生幻觉。

一种100%致命且100%传染的瘟疫正在杀死马卡布人。弗兰克林博士试图找到治愈方法，但马卡布人自己反对他，他们相信瘟疫只影响不道德的人。

莱塔·亚历山大带着心灵感应者抵抗组织的消息返回巴比伦5号：指挥部的某个成员是PSI军团的内鬼。

德拉尔向谢里登显现自己，同时雷法和隆多启动了一个计划，将导致纳恩人的最终失败。

科什召唤一个审问者来测试德琳的动机，G'Kar试图在组织地下抵抗的同时保持他作为巴比伦5号纳恩人口群的领导者地位。

和平部的两名官员来到巴比伦5号；一个处理半人马座持续扩张的问题，另一个检查当地的夜间警戒。同时，一艘纳恩重型巡洋舰寻求庇护，以便他们进行维修，而凯弗继续寻找证明阴影船只存在的证据。

Lochley takes command of Babylon 5 and Byron petitions her for asylum aboard the station. An assassin pledges to kill Sheridan at his inauguration.

Londo collapses from a heart attack, and must battle with his guilt in a dream state. Delenn learns that Lennier is planing to leave Babylon 5 to join the Rangers.

A small world plagued by raiders begs the alliance for help. Garibaldi tries forming an intelligence unit of telepaths.

We see the action from the viewpoint of two maintenance workers as a race of savage aliens attacks the station.

Four rangers come from Minbar with a status report to Delenn, while a Downbelow racketeer decides it's time to get rid of Zack.

Bester arrives at the station to arrest the Downbelow telepaths, and Londo barely escapes an assassination attempt when the ship he was to be aboard explodes.

As more telepaths arrive at the station, the denizens of Downbelow start taking notice. Tensions build until one of the telepaths is assaulted, and the others decide to take revenge - against Byron's wishes. Meanwhile, Franklin tries to find out why the Hyach are hiding part of their medical history.

The Brakiri buy a part of Babylon 5 for a religious ceremony where the dead are supposed to return. Comedians Rebo and Zooty arrive to do a show on the station.

Londo starts to suspect that all is not right on Centauri Prime, when a good friend is murdered. On Babylon 5, Byron tries to force the council to give him and his telepaths a homeworld of their own.

The telepaths have barred themselves inside an area of Downbelow, and their telepathic tricks force Lochley to ask Bester for help. G'Kar finds an old friend locked in a cell in the Centauri palace.

More bloodhound units arrive and the fight with the violent faction of Byron's followers intensifies until the rogues seize Medlab - with Garibaldi and Franklin in it.

It looks like the Alliance will get a break in the investigation of the recent shipping line attacks, when a possible witness may have survived the latest attack and taken refuge on the Drazi homeworld. Garibaldi is sent to find him, but the Intelligence Chief's alcohol problem complicates the mission. G'Kar returns to Babylon 5 to discover that his book has been published, and he is now a revered religious figure.

A telepath murders his roommate and escapes on a ship bound for Babylon 5. Bester is given the job of capturing him, and brings along two PSI Cop interns to show them how he works.

Delenn reassigns Lennier to a Ranger training mission on the border of Centauri space, hoping he can find some proof regarding the Centauri involvement in the shipping line attacks. Vir undergoes some dramatic changes when he learns that he is the new Centauri ambassador to Babylon 5.

Lennier investigates Centauri signals that may be connected to the attacks. Lyta tries to continue Byron's dream of finding a homeworld for telepaths. Lise visits Garibaldi only to discover he's drinking again.

The evidence collected against the Centauri is presented to the council of the Interstellar Alliance, and a boycott against the Centauri is issued. In reaction, the Centauri withdraw from the Alliance and make it clear that they will circumvent the blockade by force if necessary.

Sheridan finally authorizes the White Star fleet to participate in the war. Delenn travels to Minbar to start a Minbari-Earth joint project to build a prototype White Star destroyer class ship. Vir hires Franklin and Lyta to investigate why the Drazi don't return the bodies from destroyed Centauri ships.

As Centauri Prime is being bombarded, the Drakh, the real masters behind the war, reveal themselves to Londo. They force him to go along with their plan to alienate the Centauri from the Alliance, and use what's left as their new home.

Earth Force orders the arrest of Lyta for financing terrorism against the PSI Corps. Sheridan confronts Garibaldi about his drinking. G'Kar struggles with his growing mass of worshippers.

Tessa Holloran, former Number One of the Mars resistance, arrives with a warning for Lise and Michael: an assassin has been hired to kill them. Meanwhile, G'Kar gets ready to leave, though not everybody is happy about it.

It is near the end of 2262, and many changes are abound. Londo, G'Kar and Garibaldi have already left, and Franklin will be taking up his new position on Earth shortly. Finally, Sheridan and Delenn leave for Minbar, where the Alliance's recently finished headquarters are located.

Twenty years after his death and resurrection at Z'ha'dum, Sheridan feels his life force ebbing away, and invites some old friends for a final gathering.