Dr. Kenzo Tenma, a leading neurosurgeon at the Dusseldorf Hospital has received massive acclaim for his successful surgery on a famous opera singer. However, he is burdened by guilt. Due to pressure from the director, he had operated on the opera singer on the night that he was supposed to operate on another man. As a result, when the director’s orders him to operate on the mayor, he decides to ignore the order and instead works on saving the life of a young boy, brought to the hospital from the scene of a serial homicide. However, the boy's twin sister, who was brought in with the boy, and who still suffers from shock, keeps repeating the words 'kill him'.

The price for disobeying Dr. Heinemann's orders to operate on the mayor is costly for Dr. Tenma. His career begins to plummet. The boy whom he saved finally awakens, but a horrible incident occurs soon after.

Things look brighter for Dr. Tenma, now that Dr. Heinemann is dead. His career takes off, and even Eva tries to win him back. But unfortunately, all that success has drawn the attention of Detective Lunge.

Adolf Junkers has information about the serial murders that is vital to the police, but he is afraid to reveal them. Dr. Tenma's care for Adolf Junkers however wins him over. His close relationship with Junkers however leads him to a night of shocking horror.

Nina Fortner, a talented young student in Heidelberg has been having nightmares. She also cannot remember anything about her life before she was 10 years old. She soon suffers from fainting spells in university and starts receiving anonymous emails.

Nina finally receives an email informing her to meet the anonymous sender at a specified time and place.

Dr. Tenma in his search for the Liebert girl, asks Mauler, an editor for a local publisher, for assistance in his investigations.

Tenma and Nina return to the Fortners’ residence to find Mauler and Nina’s parents dead. Two detectives arrive to take them to the station for questioning, but certain things don't look right.

Eva tries to threaten Dr. Tenma, unless he gets back with her, she would reveal to the police that the tie that was found at the scene of the crime is his!

An old mercenary soldier named Hugo is interrogated by Lunge about a student of his, a doctor named Tenma.

Tenma encounters a burglar named Heckel who claims to have seen the killer. It soon results in Heckel leading Tenma to a couple of murderers.

Tenma learns that Johan used to be in an orphanage known as Kinderheim 511. And he meets a former East German official named Hartmann who used to work there and an injured boy named Dieter.

Dieter is picked up by Hartmann before Tenma could return. And Tenma learns more about the experiments in Kinderheim 511.

In a small village, Dr. Schumann worries over the health of his sick but stubborn old friend, Petra.

Inspector Lunge investigates the murder of a prostitute and suspects a senator named Dr. Boltzmann of involvement. His dedication to his work however takes a toll on his family life.

Meanwhile, the vindictive Eva continues to press Lunge to catch Tenma. She also has a new lover, her garderner.

Dr. Tenma and Nina Fortner's investigations lead them to a powerful man known as 'The Baby', who belongs in an extremist organisation.

They soon learn that the organisation has special plans for the Turkish district tomorrow.

Nina escapes the mansion. And Tenma meets with the unrecognizable General Wolf at the mansion later.

The extremists plans are put into action, and Tenma decides to postpone his search for Johan and instead heads to the Turkish district to warn the people there. Dieter and Heckel are captured by the skinheads and are left to burn in the fire. And Nina tries to get information about the 'main dish' from 'The Baby'.

Nina meets with an old friend and boss, Mister Rosso. The delightful old boss however, has a very dark past.

Tenma visits Rudy, a criminal psychologist, who is working on cases involving a murderer named Jurgens.

Tenma and Dieter hitch a ride with an elderly couple on the way to Freiham. Tenma wonders if the couple plan to turn him in.

Nina confronts Muller, one of the two detectives responsible for the death of her foster parents, the Fortners. Muller discovers that his protege, Roberto, is actually working for Johan and is now tasked with killing Nina.

Lunge determines that the murder of a wealthy, middle-aged, childless couple does not fit the usual modus operandi of the serial murders and decides to use this opportunity to lure Tenma to a trap. However, before he can arrest him, Lunge is critically wounded by the real criminal. Tenma is able to treat Lunge's injuries.

Eva Heinemann is arrested for public drunkenness and hooks up with Roberto, with whom she was with the night before her arrest. Roberto then reveals his link to Johan and Eva confesses that she was actually a witness the night Junkers was killed by Johan.

In exchange for her life, Roberto tells Eva to confront Tenma, who is currently treating a mob boss at a country house. Eva is promptly wounded by Roberto when she is unable to complete her task but is saved by Tenma.

Karl Neumann and Lotte Frank are both students who read latin to Hans Georg Schubert. Lotte attempts to assist Karl in finding out his past while trying to figure out the identity of a boy who reads to Schubert on Thursdays. When they both discover who he is, they find the boy, Edmund Farren, in his dormitory, dead.

A man who claims to be the son of a millionaire has committed suicide, and a detective is determined to solve the case.

Richard's past and present situation is revealed. Johan continues to bond with the Schuwald family and his intention is revealed.

Richard re-investigates his old homicide cases and makes a frightening discovery.

Robert delves into Johan's past and makes a shocking discovery. Dr. Gillen speaks to Peter Jurgens, a serial murderer about Johan's possible involvement and gets a tragic reply. Johan confronts Robert about Stephen Joos. And Dr. Reichwen receives tragic news from the police.

Suspecting foul play in Robert's 'accidental' death fall, Dr. Reichwen makes some discoveries in his investigations. But as he later realizes, his investigations may have put him in harms way.

Dr. Tenma and Dr. Reichwen finally meet. Dr. Reichwen intends to proof Dr. Tenma's innocence in the homicides, but Dr. Tenma has other ideas.

Lotte, Frank and Karl are drifting apart. Lotte meets Nina Fortner and they become friends. Dr. Tenma searches for a perfect spot to shoot Johan.

Dieter learns of a life threatening game that children are playing. Mr. Schuwald decides to donate his whole book collection to the Munich University Library under the suggestion of Karl and Johan.

The 'Margot Langer' impostor tries to blackmail Johan. Dr. Tenma helps a young 'doctor' at an illegal clinic

Lunge tries to get into Dr. Tenma's mind by pretending to be him. Dr. Gillen learns something about Johan during an interview with a psychotic killer. Dr. Reichwen tries to warn the Lieberts of Johan's true nature. Dr. Tenma scouts for a perfect sniping location.

Dr. Reichwein reveals the true nature of Johan to Mr. Schuwald. Dr. Tenma gets ready to assassinate Johan. Lunge concludes that Dr. Tenma will kill Schuwald next. Lotte confronts Nina about Johan.

The episode begins with a fairy tale about a Monster without a name. Nina reads the story from the picture book and has a sense of deja vu. Johan's evil plans for the book donation ceremony is carried out. Dr. Tenma meets a big obstacle in his attempt to kill Johan.

Dr. Tenma has a gun pointed at Roberto, but Roberto has the rifle pointed at him. Nina, Dr.Reichwen and Dieter arrive to find the whole library in flames. People are trapped inside and the doors are all locked. Karl reads the report on his mother's life and death. Dr. Tenma tries to rescue those trapped in the building. Johan reveals the monster inside of him to Schuwald.

Lunge, from the BKA, learns that Johan may indeed exist. Nina goes into regressive hypnosis to learn more about the picture book and her past. Mr. Schuwald has a message for Dr. Tenma and sends Karl to Dresden to pass it to him.

The episode introduces Grimmer. Grimmer is a freelance journalist doing an in-depth research into the abuses in the orphanages in East Germany. Grimmer meets with Dr. Tenma during their trip to Prague, and they become more acquainted when Tenma is faced with an immigration problem.

Grimmer stubbornly stalks Petrov for his experimental research papers chronicaling the abuses at Kinderheim 511, but he gets a surprise instead.

Grimmer has the key that Petrov gave him, and a former Czechoslovakian secret police organization wants it. Caught and tortured, Grimmer tells his abductors about 'the Magnificent Steiner'.

A new inspector, detective Suk is on the case of Zeman's homicide. During his investigation, he discovers that there is more to Zeman's murder than first assumed. Suk also meets a lady whom he falls head over hills for

After the death of his seniors, Suk is left to re-investigate case from the very beginning. He gets information from the orphans about a meeting with Grimmer. His intention to arrest Grimmer takes a different turn however when he gets deeper into the investigation. The episode also reveals that there is more to the nameless lady at the bar than she lets on.

Suk is put under surveillance by the new commissioner. Together with Grimmer, Suk retrieves the tape and research papers from the deposit box. But their movements is watched by various sides.

Dr. Tenma learns about Suk's fugitive status from a journalist. And sets out to find him. Meanwhile, Suk and Grimmer goes into hiding, but is quickly found, surrounded and attacked by the STB. The STB's assault comes to a bloody end.

Nina's experience in Prague is a nightmare for her. Tenma and Grimmer meets with a top man in the Czechoslovakian STB. They are offered a deal which Grimmer refuses to accept.

Johan visits Suk's mother. Tenma and Grimmer learns of his visit. They, including Col. Ranke, listen to Johan's tape. Lunge arrives in Prague for a 'holiday'. His investigation leads him to the sketches of Franz Bonaparta.

Grimmer and Tenma tries to stop Johan from subjecting Milo, one of the orphans, to one of the most cruel fate.

Lunge investiga el secreto que esconde la Mansión de la Rosa Roja. Tenma y Grimmer se separan, pero Tenma se encuentra en problemas.

Schubert, con la ayuda de Reichwein, reexamina su pasado con la verdadera madre de Karl Neumann y se da cuenta de su vínculo con Johan. Al difundirse la noticia de la detención de Tenma, varias personas reaccionan con conmoción y horror, a excepción de Eva Heinemann, que insiste en que Tenma pague caro su rechazo. Suk intenta salir del hospital en el que se encuentra para tratar de ayudar a Tenma, pero es detenido por la Policía de Praga, que le informa de que Grimmer les ha enviado una nota en la que exonera a Suk de cualquier implicación en la muerte de los policías. Lunge también recibe noticias de la detención, pero está más interesado en la Mansión de las Rosas Rojas, donde obtiene una carta posiblemente dirigida a la madre de los mellizos.

Antiguos pacientes del Eisler Memorial Hospital solicitan la ayuda del abogado Alfred Baul para que represente a Tenma. Baul, a su vez, solicita la ayuda de Fritz Vardemann. Vardemann visita a Tenma en la cárcel y acepta asumir la defensa, pero luego es llamado al hospital cuando su mujer se pone de parto con su primer hijo.

Tras escuchar la amenaza de Roberto contra Eva, Tenma decide confesar todos los cargos que se le imputan para que le metan en la misma furgoneta que transporta a un preso a una Penitenciaría Federal, ya que el preso está organizando una fuga.

Tenma y Milch huyen con los heridos Gustav y Helene. Eva encuentra su vida en peligro cuando descubre que el abogado con el que debe reunirse, el Sr. Baul, no es otro que Roberto.

El Dr. Tenma toma como rehén a Verderman en una búsqueda desesperada de Eva. Y el oscuro pasado de Verderman se revela.

Nina y Dieter entran en la Mansión de la Rosa Roja, pero Nina se desmaya por su inquietante experiencia. Y acaban al cuidado de un titiritero llamado Lipsky.

Un flashback al pasado de Johan y Nina, a la época anterior a los homicidios de los Liebert, revela el motivo del asesinato de Johan. La policía hace un descubrimiento sorprendente en la mansión incendiada. Tenma finalmente se entera de dónde está Eva. Y Lunge revela la verdadera identidad de Lipsky.

Martin, un asalariado, es contratado por los ex socios del general Wolf para "cuidar" de Eva. Pero sus emociones se interponen a sus órdenes.

Tenma consigue encontrar a Martin. Una Eva borracha descubre a Johan en una fiesta. Martin recibe las últimas órdenes de su jefe, pero sus sentimientos se interponen. Y Martin se ve sobrepasado cuando trata de investigar a Johan y a su discípulo, y se revela la verdad sobre su pasado.

Martin’s attempt to save Eva costs him his life, his last minutes with Tenma reveals a terrible secrets about Martin’s boss, Peter Chapek and the about the experiments.

Nina returns to the apartment that she lived in with her mother and Johan and encounters another memory. She then returns to Munich and Dr. Reichwein where she volunteers for hypnosis to find the truth behind these memories. After she nearly kills Dr. Gillen in a hypnotic rage, she leaves Dr. Reichwein's house to try to stop Tenma from killing her brother. Meanwhile, Suk and Vardemann team up to interview former residents of the Mansion of Red Roses to gather information on Franz Bonaparta's reading sessions with his picture books, and for Vardemann to find out more about his father's true involvement.

While trying to escape from police in Frankfurt, Tenma is hit by a van. He awakes in the Turkish Quarter of the city, the same one that he saved from The Baby's plot. The man who saved him plans to kill Petr Capek at a convention, but he fails at this task and is shot dead. Nina, in Frankfurt, sees the picture of Petr Capek and it triggers yet another memory.

Egon Weisbach was one of the first investigators in the murder of the Liebert parents. On his last day on the job before retirement, he is escorting a convicted serial murderer but wants to know why he killed someone who did not fit his modus operandi. At the same time, Dr. Gillen is interviewing several murderers wondering why they killed someone who also did not fit their usual targets. Both realize that all these criminals committed murders outside their usual scope at the request of a young man, presumably Johan.

Capek tries to berate Johan for his actions and tells him that everything should be done according to Capek's plans but Johan simply disagrees and disappears. Capek realizes his hold on his organization is crumbling and has his men pick up Nina in Frankfurt. Eva accosts the young man who was introduced to Johan, Christof Sievernich, demanding answers.

Capek reveals to Nina that her and her twin brother Johan are the products of a eugenics experiment designed to breed "the perfect children". Tenma has wounded Christof and is driving him and Eva to the hospital while demanding answers on Petr Capek. While Eva makes a phone call at a payphone, Tenma sneaks away.

Nina se enfrenta a Johan, quien le presenta una historia sobre lo que sucedió cuando muchas personas fueron envenenadas en la Mansión de las Rosas Rojas. Nina se da cuenta de que fue ella quien presenció esas muertes, el shock de esta revelación casi la lleva al suicidio, pero es salvada por Tenma.

Con una tarjeta postal obtenida a través de Lipsky, Lunge llega a Ruhenheim. Allí se encuentra con Grimmer, cuya investigación le ha llevado también a esta ciudad. Una pareja de clase trabajadora de este pueblo se da cuenta de que ha ganado la lotería. Temiendo que todo el mundo quiera matarlos, el marido compra un arsenal de armas.

Lunge y Grimmer llegan a la conclusión de que algo terrible está ocurriendo en Ruhenheim cuando suenan disparos al azar, la gente es asesinada o desaparece y las carreteras que salen de la ciudad están inundadas por las lluvias torrenciales. Mientras Nina se recupera en un hospital cercano, Tenma, siguiendo una pista de Capek, viaja a Praga y se reúne con Lipsky y determina que Johan está en Ruhenheim.

A medida que pasa el tiempo, más personas de Ruhenheim son asesinadas a tiros por personas misteriosas y entre sí. Tanto Grimmer como Lunge determinan que el propietario de un hotel local es Klaus Poppe, también conocido como Franz Bonaparta. Tras someter a un hombre que estaba dando armas a todos los habitantes del pueblo, obtienen información de que uno de los cabecillas está en un segundo hotel.

Tenma se encuentra con Lunge, que se disculpa por sus anteriores acusaciones contra Tenma. Nina y el Dr. Gillen acuden a Ruhenheim. Después de que la pareja ganadora de la lotería resulte herida en un ataque al hotel de Bonaparta, Grimmer sale a la calle para razonar con los asaltantes desconocidos.

Lunge se enfrenta a Roberto, uno de los cabecillas, en una habitación de hotel. Ambos resultan heridos en la pelea. Nina y Gillen llegan a Ruhenheim, donde encuentran una casa que contiene dibujos de los dos gemelos hechos por Bonaparta. Esto desencadena un último recuerdo y el secreto de la locura y los motivos de Johan, su búsqueda de la verdadera soledad, así como del perdón por sus acciones.

Bonaparta intenta matar a Johan a tiros, pero es abatido por Roberto, que muere poco después de sus propias heridas. Una vez terminada la masacre, las autoridades se apresuran a entrar en el pueblo e intentan determinar lo sucedido.

Ha pasado algún tiempo desde la trágica batalla de sangre, y todos se esfuerzan por volver a la normalidad. Tenma finalmente localiza a una mujer que ha estado buscando, y ella le revela una información sorprendente.