As Anne settles in New Orleans (aka: The Big Easy) to stay, Remy continues to try to win her affections with the help of Smiley and his other associates, while both Anne and Remy have fantasies about the other, while Lightin' Hawkins also tries to get Anne to notice him as well. Meanwhile, a fortune-telling friend of Remy's, named Zelda Riley, tells him about a premonition about a street informant being murdered. Remy investigates and soon locks horns again with Anne who suspects Zelda somehow being involved, while Remy thinks otherwise and sets out to prove it.

Remy investigates the murder of a groom at his bachelor party where the only evidence is that of a high-heeled shoe left behind by the killer who may have been a transvestite. In attempting to dig into the past of the murder victim, Anne also learns some hidden facts about the groom's real interests as well as the bride-to-be's urges. Elsewhere, C.D. tries to find time to help Remy with his investigation while planning to hold another Civil War re-enactment outside of town.

Remy begins moonlighting as a personal bodyguard to a wealthy shipping magnate when his life is threatened. But Remy cannot resist temptation to the rich guy's young wife, Isabella, while leads point to a sordid state of affairs involving a prenuptial agreement, and the man's first jealous wife. Meanwhile, Anne asks Smiley to go undercover to investigate Isabella's past involving her shady "brother" Martin connected to a local pimp who may hold a clue to the case. Elsewhere, Darlene struggles to run the station house in the absence of several officers on leave.

Remy investigates the mysterious death of a businessman whom he believes it to be the work of voodoo. While everyone, but the skeptic Anne, believes in the local voodoo superstitions, Remy sets off with Smiley to find the right culprit, while Anne decides to try out an experimentation to see if it really exists by concocting a "love potion" for Remy to notice her.

On the night of Marti Gras, Remy finds himself held hostage at his hangout, the Blue Spot Bar, by an escaped convict, named Lyle Tillman (Silas Weir Mitchell), who seeks to prove his innocence of a murder-robbery the previous year while Lyle's very pregnant wife, Grace, holds C.D. hostage in his office at the police station as another bargaining chip leading to Darlene (stuck wearing a Little Bo Peep costume) as well as Anne (stuck in a Marie Antoinette costume) to try to help defuse the situation while Smiley finds himself the errand boy between the two standoffs while Hawkins assembles a group of SWAT men (stuck in clown costumes) to plan a brash assault on the bar in spite of the situation.

In this take on 'Rear Window' one of Anne's friends, Holly, who is recovering with a broken leg, thinks she's witnessed a murder in the apartment from across the courtyard from her apartment. Remy initially doubts Holly's story, but soon launches a personal investigation into the neighbor who is an illusionist from England who may be holding more than a few skeletons in his closet. Elsewhere, Remy makes a bet with C.D. for him stop smoking cigars for 48 hours.

In the retrospective season final, Remy and Anne are abducted by a pair of redneck brothers whom Remy put away their serial killing eldest brother, leading to the mismatched detective and attorney trying to get away from their would-be killers by hiding out deep in the swamps where they reminisce about their happier and more harrowing times. Meanwhile, C.D. and Smiley figure out that Remy and Anne are in trouble when they go missing and try to find them before the Bill Brothers have their chance to lynch them.

While investigating the murder of a mysterious businessman at a kiddie park, Remy, Anne, and Smiley get drawn into a search for four parts of what appear to be a legendary treasure map leading to a hidden 18th Century pirate treasure in the area which is also sought after by a one-eyed Frenchman who may have a connection to the murder victims, and to a local barmaid who may know more than she knows about the treasure map.

While investigating the death of a wealthy businessman who died from a fall at a house reputed to be haunted, Remy and the team try to disapprove of the theory that the ghost of a scorned woman is behind it who shows up to murder three men every seven years. While Remy deals with a persistent female reporter, whom he once had a tryst with, Anne volunteers to go undercover at a local escort service to look for clues, while Smiley decides to moonlight at a taxi driver only to have his uncle's cab damaged by another falling victim.

Remy and Anne investigate the murder of a novelist who was researching a local vampire cult in New Orleans. While Remy tries to find the cult leader and prime suspect, Anne has a meeting of minds with a young research professor who had a dark past of his own.