MacGyver is on his way out of Bulgaria with a secret microfilm, when he meets Penny Parker, a beautiful, talkative American, who is on the run from her lover, a man named Stephan Frolov. She stashes some jewels on MacGyver, thus making him a suspect, and now MacGyver and Penny must flee Bulgaria together.

A 15-year-old genius accidentally hacks into a defective missile guidance system and attracts the attention of both the FBI and some black marketeers, who think that she may fix it for them. It's up to MacGyver to save her from being kidnapped by either side.

Posing as a watchmaker who manufactures bomb timers, MacGyver manages to catch a master killer—Piedra—before he attempts an assassination on a high-profile target. However, Piedra isn't about to be stopped for long.

MacGyver and Pete are testing a new security system at the Strategic Research Development Administration. MacGyver successfully bypasses the security and meets Dr. Jill Ludlam, the system's designer. She tries to turn off the security system, but it doesn't realize that it was just a test. MacGyver and Dr. Ludlam are then forced to find a way out, as the security system, named Sandy, tries to destroy the "intruders."

While MacGyver goes to pick up a Chinese friend's brother from a birthday party, he witnesses something strange: Paul is being called "The Wish Child." It seems that a greedy businessman has wrapped him up in a scam, because he looks exactly like a boy from an old legend that owns the secret of immortality. Now, MacGyver must try to talk him out of this, because Paul is starting to believe he really is The Wish Child!

MacGyver, returning home one night, walks into his apartment, only to everything he owns missing from his apartment. Initially suspecting a robbery, MacGyver eventually comes to the conclusion that his old friend Jack Dalton is the one responsible for the theft.

MacGyver puts up Penny Parker for a few days while she's looking for a job as a singing telegram. But on her first day, she happens to witness two thugs torturing a man. Unfortunately, she can't find her way back, and when she does, MacGyver thinks this may be the start of something bigger as the victim is a Federal agent.

MacGyver becomes infatuated with a woman while conducting environmental-impact studies. However, what MacGyver does not know is that the woman was hired to "persuade" him to skip the studies—and if necessary, kill him.

While visiting an old girlfriend who's a park ranger at a wildlife reserve, MacGyver runs into deadly poachers who are intent on hunting animals on the reserve. When MacGyver tries to uncover their plot, they come after him. Now it's a race against time to escape the poachers, save the animals, and save their own lives.

MacGyver returns to his home town of Mission City, Minnesota to meet up with two old friends, Chuck and Neil, so they can dig up a time capsule they buried twenty-five years before. However, MacGyver is hesitant to dig the capsule up because he is still haunted by the death of his old friend Jesse, who died when MacGyver was young. But now MacGyver has another problem to deal with. Chuck's and Neil's sons, Danny and Sean, have gotten wrapped up in a drug deal, and the dealer is after Danny. Danny takes off to hide, and now MacGyver must find him, before the drug dealer does.

Central American rebels capture Pete and a nun during a coup d'état, and it's up to MacGyver and Jack to rescue them.

MacGyver and Pete are captured by terrorists intent on wiping out a nearby city with an electromagnetic pulse, unless their leader is freed.

Jack, MacGyver, and Pete review their past adventures while on a gold-panning expedition, unaware they're being stalked by a vengeful killer.

MacGyver and an old friend dash around the world searching for the artifacts necessary to locate the Holy Grail, just one step ahead of a ruthless man on the same trail.

Mac and a bounty hunter join forces with a bulldog named Frog to track down a Bulgarian defector who was the accidental witness at a murder and who is now being stalked by the killer, who needs a map she doesn't know she possesses.

An old nemsis enlists MacGyver's help to rescue someone important to him—and she's scheduled to be executed during a Halloween Party put on by a professional assassination organization.

Pete and Mac try to help when a Phoenix Foundation engineer is seduced and betrayed by a spy seeking her prototype for a new stealth technology for submarines.

MacGyver is reunited with Lisa, whose help cleared him of assassination charges in Switzerland, when a steel plant executive kidnaps her as revenge against her cold corporate-raider father.

MacGyver risks judicial displeasure when he breaks jury sequester to investigate the scene of a racially charged murder, and discovers evidence that drastically alters the interpretation of the facts.

A close friend of MacGyver is murdered. In searching for a reason for this assassination, MacGyver discovers a secret nuclear weapons plant right in the center of Britain.