The cruise ship Juliet disappears in the Mediterranean Sea. Our heroines investigate and find out that the passengers, and even Clover, have been turned into human-animal hybrids by a famous fashion designer. In a B-story, Clover tries to impress a guy with some really tall shoes.

Sam falls for a seemingly nice boy at school, only to find out that he is using her to steal a top secret invisibility serum from the military. B-story: The girls decide they aren’t spending enough time together, so they plan a spa weekend in Palm Springs.

Animals start developing human intelligence while humans start behaving animalistically. Can the spies stop the mad scientist who's swapping personality traits and now that Clover's part beagle will they have to keep her away from fire hydrants?