The show takes a while to start, with the title music heavily extended, Thurston Moore joins the show as Ghost Planet comes under attack, forcing Space Ghost to bombard the audience with another extended musical number before finally revealing that the entire show was simply a dedication to the music of the late Sonny Sharrock.

Michael Norman isn't afraid of Space Ghost, and Bill Nye is afraid that he might never know what Space Ghost IS...

Space Ghost is forced to deal with the annoying and easily frightened Tansit who has replaced Moltar as the show's director, when Space Ghost forces Tansit to reveal where Moltar is, he leaves his special guests Metallica to the mercy of Zorak.

Mike Judge kindly asks Space Ghost to 'whack the Rugrats.' Space Ghost agrees to the job, as long as he can get onto one of Judge's shows.