Charlie and Dee have been stealing Frank's delicious meats, so Frank leaves out human meat to get back at them. Driven by their cannibalistic needs, Charlie and Dee go in search of human flesh. Mac and Dennis harass Frank for hunting defenseless animals and think it would be much more badass to hunt something that could fight back ... like a human.

Charlie, Mac, and Dennis formulate a plan to take advantage of the rising gas prices. By purchasing excess amounts now, they can sell it in the future and profit. As usual, things don't go as planned. Dee is also out to make money when she learns that Bruce is going to give the family fortune to a Muslim cultural center. She and Frank try to stop him and get the cash for themselves.

Due to the gang's latest "business expenses," Paddy's is in dire need of money. Frank buys a billboard to advertise the bar, but Dee decides to create a viral video to post on YouTube for promotion. Charlie quickly joins her, leaving Frank and Mac to hold a contest for some hot models to feature on the billboard. Naturally, Dennis joins the competition to prove his worth.

Charlie finds out that the waitress has been seeing someone. He calls on Mac, his so-called best friend, to find out more information about the guy and to beat him up. However, it turns out that Mac is the guy the waitress has supposedly been seeing. Dennis, heartbroken that he's not Charlie's best friend, tries to win him over.

Part 1 of 2. Mac and Charlie fake their deaths to avoid the wrath of Mac's father who was released from prison and is out for vengeance.

Part 2 of 2. Dennis, Frank, and Dee find unique ways of coping with the apparent loss of their friends.

Charlie and Frank awake to find poop in their bed. Neither will confess to being the owner, so they, Mac, and Dennis try to scientifically deduce who dropped the deuce. Dee wants to do something a bit more sophisticated, so she invites the waitress and Artemis to a girls' night out.

A newspaper critic is kidnapped by the gang after he calls Paddy's pub the worst bar in Philadelphia.

After discovering Dennis' erotic memoir, Mac and Frank attempt to make some money off of it. Meanwhile, Dee and Charlie decide to spend a day in each other's shoes.

After Dee suffers a heart attack, she and Dennis try to live a healthier lifestyle. Meanwhile, Charlie and Mac take corporate jobs to get health insurance.

The gang fudge history by claiming that Paddy's Pub was responsible for cracking the Liberty Bell in an attempt to turn their dive into a Philadelphia landmark.

Hoping to make their own dreams come true, the gang sets out to give an unexpected family an extreme home makeover.

In the season finale, Charlie gets the gang to help him put together a rock opera based on his song "Nightman."

Dennis, Mac, and Frank go into real estate, while Dee sets out to be a surrogate for a wealthy couple. Charlie gets into it with an attorney over the law.

The gang tries to expand their horizons by going on a road trip to the Grand Canyon.

With a shantytown taking shape outside, Mac and Dennis try to keep Paddy's going in tough times. Meanwhile, Frank and Dee start a family business.

Frank's behavior is more bizarre than usual---so bizarre that even the gang notice---so they decide to stage an intervention.

The waitress is getting married, Dee is jealous that she's beating her to the altar, so she tries to derail the wedding.

The gang describes the trials and tribulations they went through, during game five of the World Series, in hopes the judge will clear them of all the citations they received.

The gang puts together a wrestling show for returning troops. Meanwhile, Dee finally meets the soldier that she has been communicating with over the internet.

The gang decides to expand their business by developing a number of products that they could sell at Paddy's pub.

Mac and Dennis decide that they need to spend some time away from each other. Meanwhile, Charlie helps Dee search for her cat.

Dennis reveals his foolproof system for seducing any woman to the rest of the gang, but they don't grasp the concept.

When Dee gets a part in the new M. Night Shyamalan film, Mac and Charlie seize a chance to pitch their movie script.

After being banned for 10 years from a local drinking competition appropriately named "Flipadelphia," the gang tries to reignite their old rivalry with another local bar. Finding that they are in need of some serious practice, the guys head to Dennis' old fraternity house at the University of Pennsylvania to get their game up to speed while Dee hones her skills on her own. Frank wears skinny pants.

Mac defends traditional marriage, while the rest of the gang reaps the rewards of wedded bliss.

Marital bliss turns into business, as the gang experiences the emotional and economic hardships of divorce.

The gang attempts to find adventure on the sea after they purchase their 'new' boat.

Mac finally gets his big break after correctly answering a trivia question on the radio. While Frank, Dennis, and Dee take their bar-banter to the internet with their own podcast.

Rejected from a pool club, Mac and Charlie set out fix an abandoned pool to help cope with the Philly heat wave. Meanwhile, Dennis and Dee go about dealing with the heat in a different way.

Mac's mother is left homeless after she burns down her house, which leaves Charlie and Mac with no choice but to make new living arrangements; when Dee feels under the weather, Frank tries to muster his paternal instincts to care for her.

The gang gets a real scare after Dee reveals she's pregnant, forcing the guys to recall their last hazy Halloween party to determine who the father is.

A blast from the past prompts the guys to expand membership, and Dee to re-consider her future.

Motivated by the drama teacher who inspired her, Dee takes a job as a substitute teacher, and exposes her students to the culture of Paddy's with a field trip to see the Gang's take on the Lethal Weapon series: Lethal Weapon 5.

Keeping the basement rodent-free drives Charlie to the brink. The gang throws Charlie a surprise party.

En route to Atlantic City for a charity event, Mac, Frank and Dee get lost. Meanwhile, Dennis and Charlie hitch a ride to town.

Dee's blessed event is fast approaching but the father's identity remains a mystery---to the gang, at least. So they throw a party and invite all of Dee's former flings.

After years of being mistreated by Frank during the holiday season, Dennis and Dee decide to teach him a lesson. Meanwhile, Mac and Charlie reflect on their childhood Christmases, and realize that they were not as joyous and wonderful as they remembered.