The McStay family disappears from their San Diego home without a trace. There are no signs of foul play and no indication that they were running from anything. Could the McStays have intentionally walked away, or did something more sinister occur?

At midnight, Patti Adkins leaves her shift at the Honda factory and vanishes. Investigators learn of a mysterious relationship and a secret trip that was supposed to happen that night. As clues emerge, detectives piece together a troubling picture.

Brian Barton has a successful punk rock band in Seattle, Washington. But Brian suddenly quits the band, breaks up with his fiancée, and disappears. Investigators wonder if he walked away, killed himself, or if his bandmates committed foul play.

After an argument with her boyfriend, 18-year-old Roxanne Paltauf leaves an Austin Texas motel on a balmy July evening and doesn't return. With her belongings left behind, family and friends speculate about what could have caused her disappearance.

Jeremy Alex races out of the woods towards a house in Northport, ME. He tells the owners that "bad guys" are after him but runs away before they can get help. Searches for him yield nothing until four years later when an intriguing discovery is made.

Toni Lee Sharpless has some demons in her past, but she's pulled her life together with a rewarding job and an adorable daughter. But a night on the town threatens this stability, sending Toni over the edge and leading to her dramatic disappearance.

After the deaths of her parents, 23-year-old Leah Roberts leaves her North Carolina home on a soul-searching journey. But when her Jeep is found nine days later wrecked and abandoned in a Washington national park, police and family are stymied.

Ray Gricar has made a long career as a District Attorney, prosecuting Centre County Pennsylvania's toughest crimes. However, when he doesn't return from a short country drive, investigators struggle to pick up the pieces.

When Sherill Levitt, her daughter Suzie Streeter and friend Stacy McCall vanish from a house one night, the town of Springfield is left reeling. A violent criminal in the area says he knows where the women are buried, which only stirs up more questions than answers.

Rebellious 18-year-old Samantha Bonnell vanishes during a night out with friends. Her mother begins a harrowing search with no help from police. When Bonnell’s suitcase turns up miles from where she was last seen her mother hopes it isn't too late.

Brandy Hall is a role model to her family, friends and the entire community where she lives. The 32-year-old mother of two worked as a paramedic and firefighter in the area for over ten years, but after a devastating year in which her husband is arrested for marijuana cultivation and she loses her job, she mysteriously disappears. Less than 24 hours later, Hall’s truck is found submerged at the bottom of a pond and it's only the beginning of a series of mysterious clues that baffle investigators and leave Hall’s loved ones bereaved and confused.

When 33-year-old Patty Vaughan’s minivan is found abandoned with a flat tire just 24 hours after she reportedly left her three kids and estranged husband behind on Christmas day, her family fears the worst. Could Patty have asked the wrong person for a ride to work after her blown out tire? All indicators point to an abduction, but as the race to find Vaughan ensues, clues start to emerge that paint a very different picture of what might have happened to the mother of three.

Rachel Cooke, a 19-year-old college student, goes out for a jog and disappears. Texas Rangers, FBI agents, and hundreds of volunteers hunt for her on foot and horseback, while divers comb local waterfronts and loved ones hang flyers. Cooke has no known enemies and no reason to run away, but the extensive searches yield nothing. The case grows cold until a new suspect offers a shocking story that could finally put the mystery of Cooke’s disappearance to rest.

Steven Koecher’s car is found abandoned near Las Vegas – two hours from his home in Utah. It’s a shock to those who know the young and well-liked journalist. As police retrace his steps, family members learn it’s been two days since anyone is known to have seen or spoken to Koecher. The car’s location in an upscale retirement community is an unlikely place for someone on the lam to ditch a vehicle, and Koecher isn’t the type to just take off. Yet there’s also no sign of violence or a suspect with a motive. Then, as his frantic family launches an all-out search, tantalizing stories emerge and bizarre hypotheses, clues, and sightings start to accumulate

Virginia Tech student Morgan Harrington promises to meet her father the morning after attending a Metallica concert, but she never shows up. Her panicked parents learn that Morgan left her friends during the concert and never came back. Witnesses paint a strange picture of her behavior outside the concert venue: she was erratic, belligerent, incoherent, and in the company of three young men. Even more bewildering are multiple reports of Harrington hitchhiking late at night on a dark road. Weeks and months go by without solid leads until forensics link Morgan’s disappearance to a violent crime in another city three hours away.

Charlie Allen Jr. is excited for his future as a doctor and aspiring tennis professional. But he sends his family into a panic when he reports to his sister that people are after him. His parents try desperately to reach their son, but all attempts are futile. A few days later, police discover Allen’s backpack in a yard, his car abandoned in a campus parking lot, a link to a local break-in, and receive reports that he was seen running shirtless and shoeless along a wooded road. Police find no sign of foul play, but also no sign of Allen. As the investigation probes further, some wonder if the threat to Allen came from someplace much closer to home.