Houtaro and his friends are in high spirits once they formed the Kitchen Ichinose Alliance. However, Rinne is still dispirited as she wonder if this is the 'rules' she had to follow as an alchemist.

While Rinne is elated to know that Fuga is in fact not a traitor at all, Minato suddenly comes to her and invited her back into the academy! While this might be the right thing to do as an alchemist, Rinne is shaken by her former teacher's invitation. Meanwhile, Atropos arrives with a new Malgam and ordered the Malgam to exclusively attack Rinne. With Gotchard struggling, Rinne is cornered!

What did she see in Atropos? Now, the sleeping power inside of Rinne will be awakened! Now transform into Majade, Rinne Kudo!

Renge has fallen under the spell of Zukyumpire. Zukyumpire attracts many men and women, but when Houtaro and his friends investigate, they discover that Renge and the others are in danger...!?

Meanwhile, Geryon, who has failed to dye Supana with malice, begins a new course of action using Clotho!

Houtaro and Rinne try to stop Zukyumpire, who steals energy from people. Then, Renge and others bring one of the Zukyumpire worshippers, Yui, to the scene.

Houtaro and the others, after hearing from Yui about the circumstances surrounding Zukyumpire, desperately try to persuade him. When Zukyumpire learns that he has been tormenting people, he is devastated, and at the same time, something strange happens around him. At the same time, strange happenings occur around them, and Clotho shows up to take advantage of them..!

Renge, who was visiting her grandmother's village, informs Houtaro and the others that a yokai has appeared and she wants them to come immediately. In that village, a man named Starshine Hoshino, who calls himself a specialist in exterminating yokai, appears, and his apprentice is Kajiki!?

Houtaro and Rinne arrive in the village and immediately discover the yokai! Houtaro transforms into Gotchard...!

The village chief is found in a grisly state, and the villagers assume it is the work of Starshine Hoshino and make a big fuss. They lock Hoshino and his apprentice Kajiki in a warehouse.

Kajiki would never attack anyone. As Houtaro and the others begin their search for the real culprit, a new Malgam appears. Houtarou transforms into Gotchard, but he feels something strange about the Malgam's behavior. What is this discomfort? And what is the truth behind the incident...!?

The Dark King Gigist appeared at the Union headquarters. Supana, angered by Gigist's defeat of one of the Union leaders, transforms into Kamen Rider Valvarad. He boldly attacks Gigist, but...

Gigist appeared in front of Houtaro, took away Skebows' card, and turned it into a Malgam. Houtaro transforms into Gotchard and challenges the Malgam to save Skebows, but he feels something strange in the battle...!?

Houtaro and others show Kyoka the completely white Skebows. They want to somehow regenerate Skebows! Houtaro and the others look at it as if praying, and Kyoka...!?

Hopper1 sets off alone on a journey to find "something" to cheer up Houtaro. Meanwhile, Gigist has taken Antrooper from Houtaro and turned it into a Malgam. The Malgam attacks people, and Houtaro and the others...!?

It was the Underworld King Germain and Gaelya who descended to earth from the Ouroboros world. Their target is Fuga, the father of Rinne, the most powerful alchemist. The Three Dark Kings, including Gigist, are closing in on Fuga.

Houtaro, Rinne, and Supana rush to the scene and transform into Riders! They confront the Dark Kings to protect Fuga, but they are cornered by the unprecedentedly vicious power used by Germain and the others...!

While Houtaro and the others continue their search, Nijigon is wandering the streets, refusing to return until he finds something he can do to help. Nijigon meets a woman practicing dance.

Germain appears before Houtarou and the others again. Together with Rinne and Supana, they transform into Riders and face Germain with a strong determination to defeat him!

People's memories come back and information spreads that Chemies are terrifying entities that turn humans into monsters. The town is in a state of panic, filled with people who fear Chemies and Malgams, and those who want to obtain Chemies and use them for evil purposes.

Then, Golem Gouriki appears before Houtaro and transforms into the Gorilla Malgam. The alchemists are accused of being the masterminds behind the series of disturbances. If nothing is done, the world will be in chaos... Supana makes a decision and takes action!

Supana summons Houtaro and the others, erases the Chemy Cards so that they cannot be re-sealed again, and takes all the Chemy Cards from Houtaro and the others. However, Kyoka and Lachesis appear and reveal Supana's true intentions in front of Houtaro and the others.

When Houtaro learns the horrifying truth about Supana, he approaches Supana with fury. "Why are you always like this?" Houtaro and Supana finally clash!

Rinne, who is suffering, disappears from the presence of Houtaro and the others, and is kidnapped by Gaelijah along with Atropos.

Rinne's life will be in danger if nothing is done. Fuga and Glion, who has called for help, head for the rescue of Rinne and the others, only to find Gaelijah's evil trap awaiting them...!

And what about Houtaro, who arrives late to the scene!?