The fierce battle between Ex-Aid and Genm has now come to an end. Meanwhile, a woman who was injured, Sora, is brought to Emu and Hiiro. Sora's band members argue, when suddenly all 3 of them are taken over by Bugsters! And on top of that, when Emu tries facing them alone, a young man appears yelling, "Yossha Lucky!"

Recently, Emu has been feeling a little worried. He is very quiet and hasn't talked much since Poppy Pipopapo suddenly disappeared. Just then, Hiiro is shocked by the sheer number of emergency calls coming to CR, all reports of the game illness! As the only CR doctors, Emu and Hiiro rush to the indicated locations, but what they find there is an unbelievable sight...

Kamen Rider Chronicle has already begun! Para-DX has joined the game and defeated the first round of the general players, giving them a Game Over as Emu watched them disappear before him. Kamen Rider Chronicle is being sold at an extremely fast rate, which catches the attention of the Ministry of Health. To avoid any form of confusion, Kyotaro Hinata orders a temporary halt on the actions of the doctors in CR. However, a game disease patient escapes from CR in an attempt to cure his own game disease, which leads Emu to chase after him. Then suddenly, Poppy Pipopapo appears before them with a new Driver and a Rider Gashat of her own…

Thanks to the public announcement by the Ministry of Health, the number of Kamen Rider Chronicle players seems to have decreased significantly, which would subsequently reduce the amount of game disease patients. However, unbelievable information about Kamen Rider Chronicle is released by Ren Amagasaki, the new CEO of Genm Corp. There is a hidden component inside Kamen Rider Chronicle, one that is said to dramatically increase player participation! However, Taiga, who was suspicious of the love and go CEO's actions, goes into Genm Corp. to confront him himself...

Ex-Aid and crews have gained the right to challenge the advanced Bugsters in order to clear Kamen Rider Chronicle. The three advanced Bugsters are Parado, Graphite, and Lovelica. The time of the final battle against the four Kamen Riders is at hand! At last, the curtain rises on the scene of the last battle! However, a disturbing darkness suddenly begins to appear...