Vash is looking for a renowned gunsmith named Frank Marlon. He finds him - but the legendary craftsman is a drunken mess! Making things worse, a group of bandits has learned that there’s no sheriff in town!

During a bus trip to May City, Vash, Meryl, and Milly encounter a priest named Nicholas D. Wolfwood. Before too long, the travelers finds their journey interrupted by a horde of attacking robotic spiders!

Vash is thrown in jail after being accused of killing a local shoemaker. Even if he gets out of his cell, there’s going to be trouble -Monev the Gale is gunning for him after being hired by Legato!

Vash and Wolfwood are in danger on the Project Seeds ship. The Puppetmaster’s goons - members of the Gung-Ho Guns - are on a killing spree and the entire ship could be destroyed.

The greatest battle of Vash the Stampede’s life arrives as he faces-off against Millions Knives. One brother wants to destroy mankind. One brother must stop him at any cost.