After Meryl and Milly’s search for the legendary Vash the Stampede leads them to an encounter with a dangerous group of bounty hunters, an unlikely hero arrives to save them.

A flashback offers a glimpse into the distant past of Vash the Stampede, his brother, Millions Knives, and the enigmatic Rem Saverem.

Vash and Wolfwood are in danger on the Project Seeds ship. The Puppetmaster’s goons - members of the Gung-Ho Guns - are on a killing spree and the entire ship could be destroyed.

The greatest battle of Vash the Stampede’s life arrives as he faces-off against Millions Knives. One brother wants to destroy mankind. One brother must stop him at any cost.