When a musician is found murdered at a Country Music Awards ceremony, Dr. Sloan and company rush to find the culprit before the show ends and the crowd disappears.

Mark, Jesse, and Amanda are trapped in a hotel when it's quarantined after a deadly virus is released. They struggle to contain the virus, while at the same time trying to locate its origin. Meanwhile, a scheming seductress carries out her plan, using the virus as a diversion to rob a nearby bank vault.