After telling his mother, he wanted to leave school for good, seventeen year old Andy Deaver vanishes from his private boarding school, last seen by it's headmaster, Graham Spaulding.

Third-year-resident Anwar Samir vanishes from the hospital he works in. Because of his Saudi-Arabian background, suspicions of terrorist links arise.

Delia , a television reporter, disappears in the middle of the investigation of a nightclub owner who is a suspected drug dealer. They also discovers that Delia was working on the case of a murderer on death row who she thought was innocent, and who might be linked to an assistant district attorney working with Jack on the case.

Jack's methods for investigation of child molester could result in the case being kicked out of court. Then on top of that, the Office of Professional Responsibility decides to investigate the team, but their real target is Jack

The team investigates when Aaron Gibbs ends up missing one night and soon learn that he had been lying to his wife about quitting his job, and had been working nights in a fight club. During the course of the investigation, Jack and the others learn that Aaron's disappearance was connected to events that took place during Hurricane Katrina, when Aaron was fighting to save his sons, and follow the trail of evidence, believing that the events of that night in New Orleans hold the key to finding the truth about the missing man.

The team tries to determine whether or not the recent disappearance of an air traffic controller has connections to the Middle East. The team soon learns that his wife died in an automobile accident and he was having an affair with her sister.