Jane McDermott is a 32-year-old former drug addict. She was convicted for murdering her father and is now serving a life sentence for the crime. She had always claimed to be innocent, and now the National Justice Project believe her and have taken her case.

A high school athlete was convicted of murdering a college girl eight years earlier. His sister contacts the National Justice Project for help because she believes her brother is innocent and this is her last hope.

The National Justice Project takes the case of a teenager who was convicted of murdering his own sister. Conti takes this case very personal because of a similar case he worked on when he was a police officer.

Donald Brooks was convicted for the murder of an unborn child in 1999, during a burglary and violent fight with the mother. A former jusro asks the National Justice Project to reopen the case because he now believes Brooks was railroaded.