In the one hundredth episode of CSI: NY Mac faces his most deadly foe yet. There is a serial killer loose in New York City killing people with the name Mac Taylor making Mac a target.

A Russian tourist is found stabbed to death and the CSIs come face to face with the frightening realities of human trafficking. Solving this case becomes personal when it directly affects a prominent member of the NYPD

When the Deputy Mayor's dead body falls from the ceiling, along with hundreds of balloons, at a charity fundraiser, Stella and her date find themselves in the middle of the crime scene and Mac goes head to head with Robert Dunbrook.