Danny and Stella find innovative ways to process a crime scene while Danny is trapped in a panic room with the victim, who was the only person with the security code. As a locksmith works to cut through the titanium doors, the CSIs rush to process the evidence before the victim decays further and Danny's oxygen runs out. Meanwhile, Mac, Dr. Hawkes and Lindsay investigate the murder of an exotic dancer found dead on a klieg light

Lindsay, Stella, and Mac are on the case of a dead ADA, who they discover, is involved in a "kill war" with water guns. Meanwhile, Danny and Hawkes investigate the murder of a young lady who had a penchant for suing restaurants and taking them for all they are worth.

A man dressed in a superhero costume is found dead in an alley, after saving a man being mugged. Mac, Stella, and Dr. Hawkes find his clothes in a nearby phone booth. Danny and Lindsay investigate the murder of an NFL first-round draft pick, known as "Superman."

The body of a man is discovered on the Brooklyn Bridge, and the only evidence is a huge marriage proposal in lights. The CSI team works through the investigation as they learn to deal with a new medical examiner.

Three women who are dressed as Holly Golightly rob a jewelry store and injure other shoppers in the process. The CSI’s must work through the confusing investigation to hunt them down. Meanwhile Mac has to identify a mummified body discovered in an apartment building that was being torn down.

The next case takes us back to Dr. Sheldon Hawks' past and the reasons he chose to change jobs in the medical profession. The CSI team may find it extremely difficult to find out who committed the murder of the 19-year-old woman who recently started recovering from an accident.

The CSI team has a problem after learning the family is deaf: now they have to find a new way to catch the killer. Meanwhile, more information is given on Lindsey's horrifying past and what led her to become a CSI.

Danny and Mac have to go to Noah’s Ark to find out if a broken promise leads to his murder. Stella and Sheldon investigate the death of a man dressed as a cigarette. Stella hopes to have her job after not telling Mac that she may be HIV right away.

After Flack makes an enormous drug bust, and locks it up at CSI, the drug lords infiltrate the building at gunpoint to get them back. Now the team must resolve the hostage situations, all the while with Mac, Stella, and Hawkes trapped inside.

The latest murder case takes Detective Taylor to a whole new world and he must figure out why Cheryl Duncan looks so life-like. They also discover something shocking about the murderer while online.

The CSI team goes to a haunted house to solve more than just the latest case. Before they can solve the crime Lindsay is told something will happen to her if she doesn't leave soon.

After the CSI's receive an anonymous tip they're led to an old warehouse hoping to catch one of New York's most-wanted criminals.

When a man takes hostages during a failed attempt to rob a bank, Mac offers himself in exchange for a hostage. Only condition is that he must prove that the bank robber did not kill the bank manager, whose body is found lying in a pool of blood in the vault. On the outside of the bank, the rest of the team works to process the evidence that Mac finds and stop the SWAT team from making matters worse.

When the wife of a former medical examiner is found murdered, a white powder found at the scene provides the CSIs with a major lead in tracking the killer when it is discovered that the powder is heroin made from human bodies.

The most exclusive jewelry auction of the year ends abruptly when an appraiser is killed during the event. The investigation takes an emotional turn when the CSIs must confront one of the greatest tragedies in human history - the Holocaust.