In the third season premiere, Ed's got major problems as the revamped Montecito struggles to finish work in time to re-open on new boss' Monica Mancuso's (Lara Flynn Boyle) schedule as he also tries to lure back Danny and his former staff to prevent a suspected "smash-and-grab" heist that has hit other casinos. But convincing Danny and the gang proves to be difficult since each has his or her reasons for leaving, and what's more, Ed suspects two construction hard-hats are planning an inside robbery once the Montecito's doors swing open again amid much fanfare.

The casino has reopened. Ed and Mike work on a case of counterfeit casino chips. Per his accountant's suggestion, Danny must sell his father's house. Later, Danny's accountant is part of a poker game where one of the players is a man who robs one of the casino's guests. Monica Mancuso, the new owner, wants a dealer to be fired because he keeps dealing winning hands to the players.

Danny is with blackjack player Gabe Labrador who's wearing a wig and counting cards. The man doesn't want to stop playing and claims he must win big to pay off the men who kidnapped his daughter. Ed, Mike, Danny and a cop from Metro work on the case even though they aren't sure Gabe is telling the truth. Mary seems to still be helping Danny taking care of his dad's stuff. She is still dating Jake. A player who won a lot of money wants to give it back, but then wants it back, then wants to give it again, etc. Sam and Woody (from "Crossing Jordan") are getting very well acquainted... Jordan from "Crossing Jordan" is also in this episode.

Sam's whale is named Trey Cooper, a handsome 30-year-old who brought his Great Dane to the casino. There are a lot of dogs around the casino as the Nevada State Dog Show is taking place. Jillian enters the Deline's dog in the competition. Monica and Danny meet with an 80-year-old woman named Dottie. Monica offers 3 million for Dottie's house in order to build a golf course. Things will become complicated when on the demolition site, construction workers find a skeleton. A CSI believes it could be the body of Seymour "Blue Jaw" Magoon, a member of a 40s gang called Murder Inc. Mike helps a couple who's "stuck" together. Jake seems to still be in Mary's life. Mike is still helping Danny to find information on the woman his father was dating before he died.

Sam's brother is staying longer than expected because he's having an affair with Monica. Danny tracks down the woman who appears on pictures with his father.

A necklace with a priceless gemstone, the Star of Kashmir, is being stolen while on display in the Montecito.

The Montecito hosts a comic book convention. Mary is checking into the Montecito for a while. Sam is after the black book of one of the world's greatest casino hosts, who just died. Monica wants Danny to be less like Ed. Danny is worried about the Montecito and calls somebody behind Monica's back.

Following Monica's sudden death, Danny becomes the main suspect. Danny and Casey arrives at the Montecito for a hostile takeover, but it appears that Monica's will leaves Montecito to a foundation for the blind. Mike is assaulted in the stairway after breaking up a fight, which leaves Danny, Ed and even Mary to find out whom could do something like that to Mike. Ed takes care of Monica's will, and her belongings.

Almost three million dollars have disappeared from Montecito. The gaming commission has to clear Casey's licence and the missing money becomes an issue. Despite being dead, it seems Monica still gets Montecito in troubles. A live weather report is to be aired from inside the casino, when the weatherman gets an allergic reaction, allowing Mike to take his place for one night. Danny and Mike is to find the missing millions, and the thief, no matter if the thief is dead or not.