When a diamond is stolen, all the signs indicate that a Lithuanian Wolfhound breeder named Falsetto Jones is the thief. Kim and Ron enter Rufus into a dog show as a Peruvian Hairless in hopes of confronting Falsetto and getting the diamond back, though will Rufus actually be able to play the part?

When Kim catches a cold from her brothers before a mission, she soon discovers that it’s hard to save the world when you’re not feeling well. Dr. Drakken and Shego exploit the moment to steal a laser from the research lab Kim is guarding. However, when Kim’s sickness begins to spread, a series of events occurred that not even she could expect.

Kim, hoping not to be landed with Ron as her science project partner, instead gets a brainiac who won’t let her do anything at all. Monique gets Ron and quickly becomes exasperated by his trademark laziness. Meanwhile Drakken charms DNAmy into creating a vicious Komodo dragon.

To help his son's ongoing quest to become a pop sensation, Senor Senior, Senior kidnaps the Oh Boyz band to blackmail the record company. The plan backfires when Ron winds up captured along with the group. The record executive, finding the Oh Boyz' disappearance to be a profit windfall, is in no hurry to help so Kim must find Ron and the others on her own.