Danny's new ghost powers are put to the test when the school cafeteria's all-vegetarian menu arouses the ire of the ghostly Lunch Lady, a 50-foot shambling pile of mystery meat who seeks revenge and a return to high-cholesterol diets. It's up to Danny to push her back in the fridge where she belongs.

Skulker, a predatory ghost hunting legend who fancies himself a collector of all things rare and unique, has set his sights on Danny Phantom, the world's only half-ghost/half-human hybrid. The games begin, as good and evil ghosts face off.