Asten forces Quincy to take some unwanted vacation time and brings in a temporary replacement, Dr. McCracken, a pathologist rather than a Medical Examiner. That very same day the body of a controversial Congressman, Laurence Bridges, is found at the bottom of a flight of stairs in his office. With the press and police wanting a quick answer to what happened to Brideges Quincy is convinced that McCracken will not do a thorough enough job. A personality clash occurs between him and McCracken as he tries to get himself involved in her case.

Mr. & Mrs. Estes have baby twins and with Bill Estes working all day Madeline is finding it harder and harder to look after the two boys. One night one of the twins dies suddenly in its sleep. All the medical and police personnel involved thinks that the baby died from SID (Sudden Infant Death) Syndrome, but a new, young and ambitious ME, Dr. Gauge, thinks that it was battered and calls in Lt. Monahan.

Bill, remembering how his wife was getting angry with the workload of looking after both babies begins to think that she could have killed their son.

A club near Danny's burns down killing the owner, Lou Chesler. His wife, Elizabeth, is suspected of causing her husband's death, especially by an insurance investigator for the company that held her husbands' life assurance policy. He thinks she has also killed previous men in her life and warns the latest one that he could be next. The latest one is, of course, Quincy.

Quincy does battle, on a live TV show, with the author of a diet book when he discovers that a model that used it has died. His outspoken statements against the book lead to him, and the department, being sued by the author.

A nineteen-year old boy, with a malignant tumor, dies in a car accident. Quincy does the autopsy and meets the family. He goes to meet Dr. Pendleton, a doctor who deals with people who are close to death, and wants to learn how to deal with people who have just identified a loved one in a more dignified way. He spends some time with the doctor and even takes his place for a while.

A man is mugged and killed in a park, fortunately the killer is quickly found and arrested. Sometime later a gang member kills a young boy. The autopsy shows that the same gun killed the boy and the mugged man.

Quincy takes it upon himself to track down the weapon and make sure that it cannot be used to kill anyone else.

An ex-nurse, who served in Vietnam and suffered nightmares because of it, is found dead in her apartment. Her best friend, who was also a nurse in Vietnam, tries to help find the killer but has problems of her own. She suffers her own nightmares from the war and begins to fall deeper into depression and alcohol. The same thing happens to many vets when they come back from the war and Quincy wants to help her, if he can.

After running into an ex-girlfriend he had a fall-out with years ago, Quincey finds himself on the case when her husband dies and must unweave a diabolical plot to reveal the killer's identity.

When a young girl is killed in a drive by shooting a young 14 year-old boy is quickly arrested. The boy, Ethan, was part of a special program trying to get kids out of gangs and trouble. Ethan denies having had anything to do with the shooting, but if he doesn't tell who did do it or if Quincy and the probation people cannot find them then not only will he end up in prison but the special program will be closed down.

The body of a young girl is found at the side of a highway. Quincy determines that the body was moved after she died. Monahan thinks that her boyfriend, Toby Kenyon, killed her but he tells the police that she killed herself. Quincy believes the boy and asks Emily to do a psychological autopsy on the dead girl. This involves talking to her friends, family and teachers about she acted and talked over the last few weeks of her life.

Quincy and Emily's wedding is fast approaching and there are many things that still need arranging. Emily has brought in Winslow, a wedding arranger to help. While the wedding arrangements are proceeding a body comes into the coroner's office, an old man who died of natural causes in a rest home, just after his 65th wedding anniversary. After the autopsy the wife of the deceased man, Edna, comes in to see Quincy and tells him that she killed her husband.

Emily calls off the wedding when Quincy fails to make it to the rehearsal, the last straw as far as she is concerned. Quincy seems to be more interested in the tales Edna has to tell about her husbands' death. Was it murder as she claims or are her statements just the ravings of a mad woman?

Kenny Kelso, a young father, is seriously injured in a work accident and loses his arm. His arm is found and the paramedics take both him and his limb to a new place, Experiment Hope, where it may be possible to reattach them. The Doctor in charge, Gabriel McCracken, is the man behind the revolutionary new techniques and does everything he can to make sure that Kenny will be able to use his arm again.