Quincy, Lee and Danny are all in Lake Tahoe together. Quincy is there for a forensic Pathologist convention and the others for a weekend break. While they are there the guests and staff start coming down with some kind of strange illness. Quincy and a couple of other Forensic Pathologists are called in to help but when some of the patients start dying they still have no clue as to what is killing them. To make things worse the casino owner does not want to admit that anything is wrong, as it will affect his bookings and profits.

The disease continues to spread and the rest of the hotel/casino's guests want to know what is going on. They want to get out of the building but Quincy and his colleagues know that they have to keep the disease, and the guests, contained. If the disease gets out of the hotel it could cause an epidemic that could quickly spread all over the country!

Quincy and Danny go on a fishing holiday to the beautiful lakeside town of Paradise, free from their troubles of restaurant managing and Dr. Asten. Almost as soon as they have started fishing a young woman pulls her boat alongside them and thanks Quincy for coming to investigate her mother's murder! Quincy has no idea what she is on about but is affected by her pleading and agrees to look into it.

Monahan wants someone to examine a body that he thinks is involved in ‘smuggling' gems, a woman about to be autopsied is surprisingly found to be alive and Dr. Quincy is nowhere to be found. In his place is the brilliant, strict and feared Dr. Hiro.