The 1975 disappearance of an 8-year-old girl who was never found is reinvestigated after a note written by the girl shortly before she vanished turns up. Their friendship rattled many in the predominantly white neighborhood and the girls quickly became targets of hatred.

The 1999 murder of a homeless woman, whose body is found at the bottom of a river in a station wagon, is investigated.

When the body of a newly missing boy is found in a cargo container along with the remains of three other victims who vanished in 1999-2003, the team realizes they're dealing with a serial killer.

The team re-opens the case of a woman who allegedly committed suicide in 1962 when the victim's granddaughter comes forth with evidence that the note found on the death scene -- then thought to be the suicide note -- was not written in the victim's handwriting.

The team receives new evidence in a 1964 case which was then though to have been a hit-and-run. Now, a threatening letter addressed to the victim prompts Will and Kat to travel to Mississippi to re-investigate the death of a woman who was secretly involved in giving school supplies for black children.

The team re-investigates the 1988 murder of a young TV reporter. Previously unseen news footage suggests she was on the verge of breaking a huge story about the unethical practices of a plastics company.