The case of a female bank teller shot to death in her work in 2000 is reopened when the same bank is robbed again by perpetrators wearing identical masks and equipped with identical weapons as six years earlier.

When the remains of a sandhog miner who disappeared in 1947 are found in a subway service tunnel, the team is prompted to re-open the case when they suspect the victim might have been murdered for being a union activist.

A 6-month-old girl's 1982 death, originally ruled to be a result of sudden-infant-death syndrome, is investigated when new evidence reveals the baby may have drowned. Also, Lilly learns that Ray is in the hospital after apparently being beaten.

Lilly re-opens a 2003 case in which an autistic boy's parents were shot in their car when Joseph brings her information that the boy might have seen the killer.