Dom is killed in a helicopter accident that also severely injures String. Dom's niece, Jo, inherits and takes charge of Santini Air. The Company sends Locke to regain possession of Airwolf, he recruits Major Mike Rivers ,an Air Force pilot to help him find and fly the craft. Together they rescue St. John from a jungle prison and he and Jo round out the new Airwolf team.

A Japanese Kamikaze pilot who survived being shot down by St. John's father during WWII plans on restoring his honor by killing St. John and destroying a nuclear power plant.

A banana republic dictator takes St. John and the family of one of St. John's friends- who had discovered that the dictator was skimming American aid- hostage on a remote island.

The Airwolf team is sent to stop a man who has hijacked a Japanese freighter carrying nuclear waste. The man plans to blackmail the nations of the Earth into guaranteeing all diseased persons.