It's been a year since Jack lost his wife, and the emotional toll includes estrangement from his daughter Kim, who is now a live-in au pair for a troubled family. Jack is no longer with CTU, and no longer interested in that line of work - until he's summoned directly by President Palmer. The situation: terrorists have planted a nuclear device somewhere in Los Angeles and plan to detonate it within 24 hours.

Jack reestablishes his undercover identity to join a crew of suspected terrorists that may know something about the nuclear device planted in Los Angeles. Posing as career criminal Jack Roush, his only hope in proving his loyalty to them lies in the package he's carrying. Meanwhile, President Palmer deals with a curious press, including one particularly skeptical reporter; Kim tries to protect Megan from her father; and Kate Warner follows up on suspicions about her sister's fiancé.

Jack tries to undermine Eddie's mission to bomb CTU while George investigates intel leading him to the site of the nuclear bomb's construction and Kim tries to make contact with her father by heading for CTU headquarters.

George returns to CTU where he orders the medics to revive a badly injured Paula, who has vital information. Palmer comes down hard on Eric for his deception. Kim takes Megan to the hospital, but the staff accuses her of abuse. Jack locates the leader of the American terrorist cell. He learns that the woman who gave them inside information on CTU is an old enemy.

Jack begins his interrogation of Nina and pushes all boundaries in order to force her to divulge the name of her contact. Palmer is surprised and suspicious when his ex wife Sherry returns and claims to have information about a conspiracy against him from within his own administration. Kim and Miguel plan to kidnap Megan from the hospital in order to take her out of LA and away from the nuclear threat.

Jack forces Nina to help with a sting operation against her contact in the hopes that he can lead them to the bomb. Palmer and Mike try to gage Stanton's loyalty when they investigate the chopper crash. George has a final conversation with his son.

Kim and Miguel are arrested and the police plan to take them back to LA. Tony questions Bob Warner at CTU and learns more about his government connections. Palmer discovers a traitor in his ranks when the journalist whom he was holding is set free. Nina pulls a deadly countermove, setting herself up as the main player in the search to locate the bomb.

George pits Bob against Reza in hopes of learning which one is working with Second Wave. Sherry and Lynne clash over Palmer's speech to the press. Kate is interrogated by Syed Ali, who believes she knows too much about the bomb. Jack and Nina fight off a group of renegade soldiers while waiting to be rescued from the crash site. They nearly escape when Nina takes Jack hostage and demands to speak to the President.