Crockett & Tubbs reluctantly comply with an FBI request to guard their key witness in a drug overlord's trial.

The irresponsible son of a fierce, anti-drug-minded Congresswoman jeopardizes his mother's political career when he incurs the wrath of a British drug lord by stealing his shipment of drugs.

Agent Joey Harden returns to assist Crockett as part of a new division, Youth Crime Unit, that was formed by a previous partner. The YCU investigates a college professor that has created a new designer drug, Bliss.