Sport Science is an ongoing television series that explores the science and engineering underlying athletic endeavors. Originally filmed as a 12-part series that was broadcast on FSN from September 9, 2007, to April 20, 2008, the second series also appeared on FSN. Series 3 was picked up by ESPN. ESPN, who has changed the name of the series to SportScience, has yet to air new episodes. Instead, the network has chosen to air various SportScience vignettes during programs such as SportsCenter. Sport Science is a spinoff of its predecessor Fight Science on National Geographic.

The series is filmed inside a Los Angeles airport hangar or on location using a mobile laboratory. Each episode on series 1 focused on testing certain aspects of athletics, while series 2 either poses more questions from previous episodes, or tries to re-analyze sporting moments or trials and tribulations, puts a human against animals or machines, or even checking against other sports or challenging the odds with data gathered using motion sensors and accelerometers. Professional athletes are featured prominently and are used to test the limits of the human body. In addition, host John Brenkus also participated in cases where an "average Joe" was required.