Nancy has relocated to the border in search of a new life but she soon finds her past to be inescapable. Both problems and people follow her on her journey, but some have finally been left behind.

After settling her family in Ren Mar, Nancy turns her attention back to business. Later, Guillermo gives her a much-needed crash course in "running" across the border. Meanwhile, Celia gets further acquainted with life in prison. Lenny leaves Silas and Shane to care for Bubbie while he goes to the track. When Lenny returns, Andy confronts him about some family history.

Nancy makes her first successful smuggling run across the border with both drugs and human cargo. Meanwhile, Captain Till strikes a deal with Celia to get her out of jail. In return, she must gather evidence to incriminate Nancy and Guillermo. Back in Ren Mar, Andy tries to convince the family, including his father, to put Bubbie out of her misery.

After Bubbie's death, the entire Botwin family sits shiva (the Jewish period of mourning) for seven days. After shiva, Nancy is sent on a mission and takes Andy along with her. Now that shiva is over and Bubbie is gone, Lenny decides to sell the house. Meanwhile, Celia continues her flirtation with Captain Till, and Doug finds refuge with the Botwins.

Guillermo gives Nancy a new job and she soon finds working retail isn't as mundane as it appears on the surface. Celia's deal with Captain Till brings her dangerously close to the action. Meanwhile, having been left in the desert by Nancy, Andy finds himself with a pack of immigrants and a very unfriendly Coyote. Back at home, the boys battle an infestation of bees.

Nancy follows the tunnel in the back of the maternity shop and sees something she shouldn't at the other end. Dean takes a new job, leaving Isabelle to live with Celia. Meanwhile, Silas flirts with Lisa, and Doug falls in love with a vision of beauty who washes up on the beach.

When Nancy is denied a share of the incoming pot by Guillermo, she decides to go over his head to Esteban. Celia discovers the cheap medication at Mexican pharmacies. Silas and Lisa get intimate, while Shane discovers some shocking photos. Andy and Doug begin interviewing for their human smuggling operation.

A spontaneous date ends in near-violence for Nancy and Esteban; Silas reveals to Lisa that he grows pot, and she makes him a tempting offer; Andy and Doug smuggle their first customer across the border; Celia develops an addiction.

Despite their busy schedules, Nancy and Esteban try to find some time for each other. After finding out about Shane's fantasies and Silas's new and much older girlfriend, Nancy also has to talk to both of her sons. With their relationship going on, Lisa and Silas add some special offerings to her cheese shop.

Nancy learns that the tunnel is being used for more than drugs. Esteban puts her fears to rest as well as her nagging headache with a strong remedy. Celia's family stages an intervention in order to force her into rehab. Andy finds Maria and takes her across the border to an awaiting Doug. Silas babysits while Shane explores new territory with his two girlfriends.

Nancy must deal with the aftermath of Shane's exploits, her Ayahuasca trip, and more confrontation with Guillermo. Celia's struggles with her rehab partner, Barry, force her to find a new rehab facility. Doug and Maria's relationship quickly goes south and they both turn to Andy for help. Meanwhile, Silas's "sandwich" business has grown too big, forcing him to turn to Nancy for help.

A fed up Nancy squeals to the DEA to bust the tunnel while she plays it cool with Esteban. Embracing rehab, Celia sets out to make amends with her family. Andy succumbs to Maria's advances, and later comes clean to Doug. Shane impresses his girlfriends with his drug scoring abilities.

The DEA brings Nancy in for questioning and then she must explain things to Esteban. Celia travels deep into Mexico to make amends with estranged daughter Quinn. Meanwhile, Silas meets Lisa's ex-husband and Doug finds a reason to live. Nancy makes a shocking revelation to Esteban.

After showing Esteban the proof of her baby, a sonogram picture. Nancy returns to Ren Mar to her family, but still unsure of her fate. Meanwhile, Celia is held hostage in Mexico by her estranged daughter Quinn who tries to ransom her off to all her friends, but they hilariously decline to deliver the cash for her release. Back in Ren Mar, Andy, Silas and Doug discuss plans to grow pot in a national forest.

Nancy pays a secret visit to Guillermo in prison; Celia puts her time in the rebel camp to good use by organizing their supplies; Shane decides to visit Nancy's estranged sister (Jennifer Jason Leigh); Silas and Doug second-guess their choice of a pot-growing plot.

Nancy gets a surprise visit from Jill; Nancy's bodyguard goes missing; Celia's micromanaging gets her sent back to the U.S.; Silas and Doug seek law enforcement approval.

Nancy is visited by DEA agent Roy Till who has gone rogue and homecomer Celia moves into Nancy's garage. Meanwhile, Andy tries to access his brother's old bank account.

Nancy talks with her obstetrician about ending the pregnancy. After his teacher took his pot, Shane needs some help to get it back. Andy is still trying to get access to his late brother's bank account. Meanwhile, Silas and Doug need to see "The Wizard" to make their pot selling dreams come true.

It's six months since we last saw everyone and Nancy is in full bloom. Esteban proposes, and all seems right with the world until Nancy discovers there's another woman in Esteban's life. Andy, meanwhile, has gone on a spending spree and let himself go. Now he must come to terms with the new order of things. Celia, unhappy in her job at the mall, discovers an opportunity in the world of cosmetics. Shane spends an eye-opening day with Ignacio. Silas and Doug's medical marijuana dispensary is in full operation. But Deputy C.P. Jones continues his meddling ways.

Nancy learns the identity of the other woman in Esteban's life, as well as his plans for her childbirth delivery. With the help of Andy and Audra, Nancy takes matters into her own hands. Meanwhile, Celia discovers that getting rich quick isn't always so easy. Silas and Doug learn the hard way that Deputy C.P. Jones is more trouble than he's worth as the fate of their medical marijuana dispensary is jeopardized.

The tension between Nancy and Esteban mounts as Pilar adds to the conflict. Nancy looks to Andy for help, just as hes focused on his relationship with Audra. Dean offers to help Silas and Doug get their dispensary back on track, but Celia sees an opportunity and steps in.

Nancy and Andy grow closer together while they try to be good parents. In the meantime, Celia and Dean work together to exploit their product surplus.

With the arrival of new enemies, Shane and Silas needs Nancy's protection. Meanwhile, Andy plans his future with Audra, while Doug and Dean make a plan to put an end to Celia's marijuana business.

A visit from Esteban's daughter comes with new problems for Nancy. In the meantime, Isabelle joins Doug and Dean's scheme of revenge against Celia.

Nancy, Andy and Cesar team up to look for Esteban when he goes missing. In the meantime, Dean and Doug start their scheme of revenge against Celia, while Silas and Shane develop a need to protect their new stepsister.

Nancy learns of Esteban's fate and takes action to preserve her own. Andy makes a big change in his life. Dean, Doug and Celia find common ground. Silas helps Adelita with a disturbing medical issue.

Faced with the aftermath of Shane having murdered Pilar, Nancy grabs Shane and Silas and they flee the scene. Andy is then met with the decision to split town with his family or stay and fight for Audra's affection.

After hours of aimless driving, Nancy, ignoring Shane's suggestion of hiding out in Pittsburgh, hatches a plan for the family to cross into Canada. Andy is tasked with acquiring fake IDs. Silas must decide if he's willing to live on the lam. Elsewhere, Esteban must answer to authorities regarding Pilar's murder and Nancy's whereabouts.

Nancy becomes a scab labor in a Seattle hotel while Shane looks after Stevie and Doug goes back to Ren Mar

Nancy makes a deal with the concierge and Shane becomes part of a mommy group. Meanwhile, Doug is questioned by Cesar and Ignacio.

The Botwins' flight continues after a parking violation and Doug gets into a hostage situation.

Nancy brings her son back while Andy and Silas wait in a diner.

Nancy decides that her family has seen enough gunslinging for a lifetime, so to lighten things up she takes them to a Montana fair. Andy and Silas enter a butter-eating contest while Doug looks after the baby and makes friends with the carneys. Elsewhere, Nancy escorts Shane on a rollercoaster where they stir up some trouble in line.

After acquiring an RV, Nancy lets Andy navigate the road and he leads them to Pioneer Town, a former western movie set now turned off-the-grid scab city. While Nancy attempts to get the lay of the land, she instructs the family to set up a mobile hash making shop inside the RV. Andy and Silas work on getting laundry machines while Doug and Shane try to obtain water.

Nancy is met with yet another roadblock when baby Stevie gets sick leaving her and Andy to scramble to find a pediatrician. Meanwhile, Silas, Shane and Doug are tasked with unloading some merchandise at a kiddie concert.

Nancy, attempting to score some big cash, returns to her hometown where she takes up residence with Warren an old acquaintance. Andy and Doug try to secure information on where to locate fake passports. Meanwhile, Silas and Shane curiously dig into Nancy's past.

Nancy, trying to get she and her family out of the country, is continually faced with unexpected guests from her past. Andy has to get creative in order to secure passports while Doug must find his own means of obtaining one. Meanwhile, Silas deals with the possibility that Lars could be his father. Shane is left to deal with Warren who is becoming unhinged.

Nancy has a tense, one-on-one, sit-down interview with Vaughn. Andy, Shane and Warren to get more cash plus passports they'll need for the family to enter Europe. Silas continues to wrestle with the fact that Lars may be his father. Meanwhile, Doug returns to Agrestic to locate his passport.

In the season 6 finale, Nancy must free herself from the grip of Esteban in order to escape the country along with her family. At the airport, Andy attempts to calm the nerves of Shane and Warren. Meanwhile, Silas must decide whether to stay with Lars or leave with the Botwins.