In the series debut, housewife Nancy Botwin struggles to deal with the sudden death of her husband, while her best friend and neighbour Celia Hodes learns a devastating secret when she tries to catch her daughter in the act with Nancy's son.

As Celia deals with the other woman in her marriage, Nancy contemplates creating an enterprise to solve the cash-only financial issues caused by her drug dealing. Silas has to come to terms with his girlfriend's sudden departure, while Shane tries to come to terms with missing his Dad.

A mountain lion is on the prowl in Agrestic, but it's the medical marijuana facility that is causing the most havoc in Nancy's life. Faced with the dilemma of having to compete, Nancy has to get cooking. Silas makes a move on Megan causing him some colourful problems of his own and Celia and Isabel's war over weight issues gets dirty.

Nancy gets a rude awakening when her brother-in-law Andy comes for a surprise visit. Doug has an idea for a location for the faux bakery, which Nancy may need more than ever with Andy in the way. While Andy wreaks havoc in the Botwins' lives, Nancy is introduced to "The Candy Man" in order to help meet her customers' needs, and Celia drops a bomb.

Isabelle experiments, Andy gets drafted, Peter may not be who Nancy thinks he is, Silas gets high, and Nancy cuts out the middleman.

After repeatedly having her suggestions ignored by the likes of Doug Wilson and having an eye-opening car accident Celia decides to run for city council. Nancy tries to break things off with Peter because her life is currently too illegal to be dating the DEA. Things gets even more hectic when Sanjay screws up at the bakery. Andy is still trying to get into a Rabbinical school so that he doesn't get shipped off to Iraq.

Nancy does her best to cope with the loss of Conrad's help, who runs into some trouble while venturing out on his own. Andy is still trying to get into rabbinical school by writing an essay on what being Jewish means to him. And Silas deals with Megan's acceptance to Princeton in his own unique way.

Nancy is having one of the worst and busiest days of life. One of sons is missing. Shane's graduation and the deal with U-Turn make her feel like she needs to be in two places at once even though she really doesn't feel like being in either of them. Heylia's plan is put into action. Nancy tries to deal with Conrad's kiss, Celia's madness, and Kat's craziness. Everything comes to a head when the deal goes wrong.

After being threatened by U-Turn and The Armenians, Nancy goes in search of Silas and her hijacked pot. Meanwhile, Celia has Silas arrested for stealing her "Drug Free Zone" signs. Nancy visits him in jail only to discover that the pot is still in his car - the one that Celia has just driven away in.

Sanjay has a new experience. Nancy gets bruised. Conrad won't do what U-Turn wants him to. Lupita still won't follow orders. Heylia's out to handle a few things. The Amber Alert is still out on Shane. Andy gets in trouble with a couple who make him for a child molester. Silas gets to talk to Shane. Celia is still having problems with her husband and daughter. Doug begs Celia to forgive him.

As the wildfire approaches, everyone must evacuate. Nancy tells her family to pack up, while Conrad and Heylia must say goodbye to the growhouse. The authorities question Sullivan and Celia, while Shane continues to ask Nancy about Pittsburgh. As Andy deals at the evacuation center, Silas realizes the truth about Tara.

Nancy has relocated to the border in search of a new life but she soon finds her past to be inescapable. Both problems and people follow her on her journey, but some have finally been left behind.

Nancy follows the tunnel in the back of the maternity shop and sees something she shouldn't at the other end. Dean takes a new job, leaving Isabelle to live with Celia. Meanwhile, Silas flirts with Lisa, and Doug falls in love with a vision of beauty who washes up on the beach.

The DEA brings Nancy in for questioning and then she must explain things to Esteban. Celia travels deep into Mexico to make amends with estranged daughter Quinn. Meanwhile, Silas meets Lisa's ex-husband and Doug finds a reason to live. Nancy makes a shocking revelation to Esteban.

After showing Esteban the proof of her baby, a sonogram picture. Nancy returns to Ren Mar to her family, but still unsure of her fate. Meanwhile, Celia is held hostage in Mexico by her estranged daughter Quinn who tries to ransom her off to all her friends, but they hilariously decline to deliver the cash for her release. Back in Ren Mar, Andy, Silas and Doug discuss plans to grow pot in a national forest.

Nancy learns of Esteban's fate and takes action to preserve her own. Andy makes a big change in his life. Dean, Doug and Celia find common ground. Silas helps Adelita with a disturbing medical issue.

Faced with the aftermath of Shane having murdered Pilar, Nancy grabs Shane and Silas and they flee the scene. Andy is then met with the decision to split town with his family or stay and fight for Audra's affection.

The Botwins' flight continues after a parking violation and Doug gets into a hostage situation.

Nancy brings her son back while Andy and Silas wait in a diner.

Nancy decides that her family has seen enough gunslinging for a lifetime, so to lighten things up she takes them to a Montana fair. Andy and Silas enter a butter-eating contest while Doug looks after the baby and makes friends with the carneys. Elsewhere, Nancy escorts Shane on a rollercoaster where they stir up some trouble in line.

In the season 6 finale, Nancy must free herself from the grip of Esteban in order to escape the country along with her family. At the airport, Andy attempts to calm the nerves of Shane and Warren. Meanwhile, Silas must decide whether to stay with Lars or leave with the Botwins.

Three years after Nancy's selfless act to save her family, Andy, Silas, Shane and Doug live their new lives in Copenhagen. When Nancy is released early from prison and put on parole to a New York halfway house, she finds out that she doesn't need witness protection anymore.

In the Season 7 finale, Silas turns the tables on Nancy, as Shane makes one last attempt to keep her out of harm's way and the clutches of Detective Ouellette. Meanwhile, back on Wall Street, Doug schemes to keep his hedge-fund scam alive.

Nancy is rushed to the hospital after being shot as the family follows close behind. The family grapples with the tragedy and hypothesizes on the shooter's identity.

The Botwins (& Doug) are at a crossroads, romance-wise and professionally.

At Stevie's bar mitzvah, friends and family gather and Nancy tries to reconnect with her estranged loved ones.