The hospital is at crisis, and Veronica tries to save the only survivor of a nightclub fire. The patience then has to go to therapy for the guilt he feels and Veronica realizes that she could also use some therapy herself. Meanwhile, Chloe wants the respect of her coworkers therefore she changes to a more mature wardrobe and attitude. Also, Sonia butts heads with a new doctor, while the nurses see Dr. Harris romantically interested in a mysterious beauty.

Veronica treats a patient for an anorexic disorder who is almost as good as Veronica herself in the denial department. When Dr. Sands and Veronica's family confront her after St. Patrick's Day binge, she considers seeing a therapist. Meanwhile, after working with Dr. Briggs to save a heart attack patient, Chloe softens to Dr. Briggs after she learn his true reasons for becoming a doctor. While Sonia, still is silently mourning her home-care patient, she unexpectedly runs into her ex-boyfriend at St. Patrick's Day fair.

When two boys get trapped in an abandoned building, Veronica finds herself in the right place at the right time to help them. Back at the hospital, Chloe pressures doctors to perform a risky surgery to save her comatose boyfriend from brain death, and Sonia treats a psychic patient who makes a mysterious prediction about her future. Meanwhile, Briggs tries frantically to raise the funds needed to pay off his high-stakes debt with the mafia before it's too late, and Sands considers a job offer to return to Afghanistan.