A newlywed cancer patient is in a risky treatment and Chloe struggles to help her husband. Meanwhile, a man wakes up after tn years in a coma and he decides to confront the love of his life, helping Veronica to take action in her own love life. Meanwhile, Sonia gets a taste of how rich people live when she has a wealthy and eccentric patient to care for.

Dr. Joe Briggs, the new head of ICU arrives at Mercy. While, Veronica and Dr. Sands must set aside their problems to save a boy found nearly frozen in the woods. After the death of one of her patients, Chloe tries to help the grieving widower leave the hospital and Sonia continues her turn as a private nurse to an upper-crust family.

Veronica is trilled to be back with Dr. Sands but their first official date is ruined by a robbery. Meanwhile, Chloe and Guillermo are put to the test in the fast-paced, high-stakes world of the ER after being re-assigned there by the arrogant new head of ICU. While Sonia bonds with the son of the rich elderly patient, and she begins to question the lifestyle she has settled into with Valentino.