In the updated version of the popular 1990s series, landlady Sydney Andrews has made herself into the a central figure in the lives of all her tenants, especially David Breck, the son of her ex, Dr. Michael Mancini. Other tenents include publicist Ella Simms; Auggie Kirkpatrick, a sous chef; Lauren Yung, a medical student; and Jonah Miller, an aspiring filmmaker.

In the wake of the murder, the Melrose Place tenants try to go back to a normal routine. Ella learns from her boss that her job may be in danger due to a recent merger. In need of tuition money, Lauren agrees to go out on another date in exchange for money.

Jane Mancini, Sydney's sister, arrives in Melrose Place to announce that she's inherited the building from Sydney. She later threatens Ella with incriminating e-mails she sent to Sydney unless she dresses a client for a movie premiere in one of Jane's designs. Desperate, Ella asks David for help. Detective Rodriguez asks Violet about her connection to Sydney, but Violet flees her apartment through her window. Lauren meets a John at a hotel bar when Toby stands her up, leading her to make the decision to take her side job to a new level. However, Wendi, a local madam, threatens Lauren to stay away from the hotel.

As a result of Jane’s tip, the police bring Ella in for questioning about Sydney’s murder. Lauren is torn between going on a shopping date with Riley for her wedding and impressing her new boss Wendi who just set her up on a “date.” A stunned Jonah is accused of stealing a diamond necklace from a mansion he videotaped for a realtor, but becomes even more upset after Ella mentions a similar necklace that she saw in David’s apartment. Violet sabotages another employee so she can get closer to Auggie.

Riley helps Jonah film a wedding, but the two get into a big fight in the middle of the ceremony. Putting her relationship with Jonah first, Riley breaks off her friendship with Auggie, who doesn’t take the news very well. Ella discovers Lauren’s expensive new clothing and lingerie plus a large envelope of cash and confronts her roommate about the late nights she’s been working. David fears he may be responsible for Sydney’s death.

The police issue an arrest warrant for Auggie after learning his blood was on Sydney’s murder weapon.

Amanda moves into Sydney's penthouse while her Bel Air mansion is being built and takes an interest in David. Meanwhile, David and Lauren’s relationship continues to grow, and Ella uses her charms to get Jonah a new job. Also, Amanda and Michael reunite.

Jonah and Riley decide to head to Las Vegas to elope but the day doesn’t quite go as planned. Ella arranges a pitch meeting for Jonah with an important producer who is interested in buying his film. Meanwhile, Lauren calls David after she gets in trouble with one of her male clients and Auggie confesses his true feelings for Riley. Also, Michael gives David information about Sydney’ killer and Amanda bonds with Violet over Sydney, but of course Amanda has an ulterior motive in getting to know Violet.