A new "hot" Dean fills in for Dean Rivers because Dustin,Quinn, and Dustin's friends hit Dean Rivers with a model airplane by mistake.. Meanwhile, the girls' Dorm Advisor Coco has just been dumped by her boyfriend, Carl. Zoey and her friends set up Dean Taylor and Coco on a date at Sushi Rox because Coco keeps complaining about Carl.

For the first time in Zoey 101, Zoey Brooks struggles with a class, Chemistry, where she scores a "C" on a test. She is given a new tutor; to her surprise, her tutor is Logan who happens to be one of the best pupils. Zoey starts learning Chemistry with Logan behind her friends' backs. All of her friends become suspicious, especially Chase. Chase tries to find out why, so Logan lies and says that Zoey is going out with him.

This time on Zoey 101, the Great Vince Blake appears to be the ladies' man, the best school athlete and the savior of the football team. He helped PCA advance to the state championships. Little do people know though, he is in fact a cheater as Chase catches him taking pictures of a history test with his cell phone. Chase must choose not to tell and let Vince cheat more or make PCA lose its biggest football game. Logan, Michael, and the football team convince him not to tell, but Zoey thinks he should. Meanwhile, Zoey, Lola, Quinn, and Mark put healthy snacks, called Moonbars, to try and persuade the students to stop eating junk food.

Zoey's date gets put on hold when the girls are quarantined in their room because Quinn made her own germ and spilled it all over the floor. Quinn calls some biology experts and is told that they have to stay in their room in order for the germ not to spread throughout the campus. While Zoey, Chase, Lola, Michael, Quinn, and Logan are quarantined, they all have problems. Meanwhile, Quinn thinks Mark is cheating on her.