We meet the Stratford sisters, Kat and Bianca, two very different people with very different views in life. They start at a new high school Padua High School with one thing in common, they both know strategy is the key. Kat wants to save the world and get out of high school as fast as she can, while Bianca wants to climb the ladder of high school popularity as fast as possible. Can each sister find happiness after getting off to a very rocky start?

Bianca arranges a charity event for the cheerleading squad to impress Chasity. But her plan ends up raising more questions than money. Will Bianca get her flowers? Will Cameron ever get the guts to express his feelings? While Bianca waits for her carnations to arrive, Kat deals with a stalker and wonders in secret whether Patrick will send her a carnation.

Bianca asks Cameron to help her to fit in with the popular group at a party. However Bianca's dad forbids her from attending the party.

Kat learns that first impressions aren't everything when she makes a shocking discovery about Patrick. Meanwhile, Bianca decides that it's time to rid herself of her squeaky clean persona. To do this, she starts a rumor about her recent conquests with an older guy. After hearing all of the rumors, Cameron's feelings are instantly hurt.

Kat tries to break the stereotype of girls doing everything a boy can do by joining a class to fix cars. Bianca and Joey become lab partners. Chastity makes a deal with Bianca for the top spot as a cheerleader provided Joey passes his Chemistry paper and plays for the team.

Bianca and her new friend Dawn ask Cameron to help them with a new web reality show, so that Bianca can go in a shopping trip with Chastity. In order to get more viewers the girls realize that they need to be a little more adventurous. How far will they go to raise the money? Meanwhile, Kat complains about the grading system in one of her classes. Luckily for Kat, the school counselor has a personal vendetta against this particular teacher. In the end, the whole experience leads Kat to some self-realizations that she did not expected.

Kat stages a protest after Padua High enforces a new security policy and school uniforms, while Cameron has a hard time getting over Bianca who is sneaking around with newly single Joey.

Dr. Stratford wants Kat to invite Patrick over dinner and a healthy helping of interrogation. Meanwhile, all the cheerleaders freeze Bianca out, and Chastity says there's just one way she can have all her friends back.