German agents question Olivia about her "relationship" with David Robert Jones, an escaped prisoner questioned months earlier now living in the U.S. The Fringe Division investigates a threatening case where victims die faceless from their orifices suddenly sealing.

Two men kidnap a teenage boy using mind control abilities. The boy's father works for Massive Dynamic but Nina insists that the company hasn't been developing mind control, and has no idea who the two kidnappers are. The truth or falsehood of her statements are soon confirmed when Peter encounters the person responsible for the boy's abduction.

When all of the groom's relatives asphyxiate at a wedding, the Fringe division investigates and quickly ascertain that a human agency is responsible. Walter realizes that the formula for the toxin was based on research conducted by his father, Robert Bischoff, and that the killer isn't stopping with a single test of his lethal concoction.

Back “over here,” the Fringe Division investigates a bizarre phenomenon when 15 people up and down the Eastern Seaboard, all suffer retrograde amnesia from listening to their shortwave radios on the same frequency. Much to Walter’s dismay, Peter presses on with piecing together the mass destruction device. Just as alternate Olivia and Peter’s chemistry deepens, the anticipation of Olivia’s return escalates.

A series of Fringe events leads the team to the home of a woman grieving over the death of her husband, while Peter and Olivia make an effort to repair the emotional rift between them.

The Fringe team must find the pattern between tragic time loop anomalies. As the investigation unfolds, Raymond, an electrical engineer, and his wife Kate, a professor of theoretical physics, enter the picture.

As the Fringe team investigates a mentally ill patient who appears to be connected to a series of murders, frightening clues and connections are uncovered that lead Olivia to some shocking revelations.