In the Pilot, Sophia arrives after her retirement home burns down and Blanche prepares to get married.

Blanche's sister, Virginia, comes to Miami for a visit and Blanche is convinced she's after something. Later, while out to dinner, she learns just what Virginia is after, Blanche's kidney. Meanwhile, Rose and Dorothy babysit for an infant.

After a Madonna concert, the girls arrive home to discover their house has been broken into. This leads the girls to seek out means to protect themselves, including a security system, guard dog and mace. Meanwhile, Rose becomes so paranoid that the robbers will come back she goes so far as to purchase a gun.

After a dinner party, Sophia suffers an apparent heart attack with a heavy storm delaying the paramedics.

Late one evening, Rose brings a man home and they spend the night together. However, in the morning she finds that he has passed away. Even worse, she later discovers he was married.

Blanche is mortified after taking a pregnancy test which indicates she's pregnant. Then after visiting her doctor, she learns the truth, she's beginning menopause. Meanwhile, Dorothy, Rose and Sophia go into the mink breeding business.

In this pilot for another series (Empty Nest, obviously the concept was retooled), the girls' friend Renee is feeling depressed and lonely with her children grown up and moved out and her husband's workaholic habits.

Dorothy is feeling rundown, tired all the time and has a lack of energy. She is sure she is ill, but all of the doctors she visits tell her she's fine. Meanwhile, Blanche decides to write a romance novel.

Dorothy continues to seek medical advice and turns to Harry Weston for help. Meanwhile, Blanche goes on a writing binge resulting in a novel that is less then enthralling.